Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1 - Test2 - elhamkhani - TriplyDB

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

http://www.wikidata.org/entity/Q35170918

about

Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies Twists in views on RB functions in cellular signaling, metabolism and stem cells RB1: a prototype tumor suppressor and an enigma KDM5 interacts with Foxo to modulate cellular levels of oxidative stress An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer An high-throughput in vivo screening system to select H3K4-specific histone demethylase inhibitors Kdm5/Lid Regulates Chromosome Architecture in Meiotic Prophase I Independently of Its Histone Demethylase Activity Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation Histone demethylase RBP2 is critical for breast cancer progression and metastasis.The Epigenomics of Embryonic Pathway Signaling in Colorectal Cancer.Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis.Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells.KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex Histone lysine demethylases in mammalian embryonic development.Exploring the tumors of multiple endocrine neoplasia type 1 in mouse models for basic and preclinical studies Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer.H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence.Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells.Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation.Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer.Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds ATM mediates pRB function to control DNMT1 protein stability and DNA methylation.Retinoblastoma-binding protein 2 (RBP2) is frequently expressed in neuroendocrine tumors and promotes the neoplastic phenotype.Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets.Recent advances in the ARID family: focusing on roles in human cancer.KDM5 lysine demethylases are involved in maintenance of 3'UTR length.Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases Conserved RB functions in development and tumor suppression.On the role of retinoblastoma family proteins in the establishment and maintenance of the epigenetic landscape.Sus1/ENY2: a multitasking protein in eukaryotic gene expression.Histone demethylases set the stage for cancer metastasis.Menin: a scaffold protein that controls gene expression and cell signaling.

P2860

Q26750380-A1AEBC76-B1E7-4405-917A-CB44F164008E Q26828495-0828ACC5-8B1B-438A-8F39-38C62B96922D Q26866393-15F48C97-44CA-4CEB-8F07-933A632BC4F5 Q27312723-FB5E8612-F530-43FF-BE48-F47D257E9090 Q27704919-43FBCA05-7987-401D-BB35-30A36EB47D82 Q28511595-A8780D75-0ADB-4C4A-8EA9-F75073507E52 Q28537878-B89465F4-A7EE-45E1-93BF-0AB4F6C4B5A1 Q28539276-CFC02C07-0C12-45EE-9E48-BE43AA06ABB5 Q28553392-8D9B1612-56CA-43F5-B607-AE3DD41CD723 Q28818255-80EB53D1-4626-43B1-A88D-55ACAE0A426A Q33557525-6C530263-84D0-42A8-99D9-2AD95FA7BCB3 Q33582497-390B2007-A236-4B60-B831-B0E2311E6D26 Q33705036-EE7CC519-B7E3-46D2-9332-38C28C3B067E Q33960142-DFE4BE8E-D611-4316-AB5C-D8037FF2F1BF Q34221649-0239C2A6-7C49-433D-9BFB-6E7A7DE3C94C Q34322749-ABD8893D-05D7-459B-A38F-256A293BA4D4 Q34355649-205795D7-0132-471E-8F87-8D1ED98C7489 Q34555991-08C196C1-77DD-456E-AE36-A85CC6015D10 Q35082433-4E48CA93-42F9-4D45-AA59-A4BCD98F9324 Q35971184-E1EC83AE-9A23-4D8D-B63F-CD1E0E8A3FF3 Q36061456-F497943C-4DBC-4055-90F9-146463F635B2 Q36070426-E9B761E2-A930-4A6E-9266-7B4F6C6254CA Q36185349-72C5BB52-29EE-4274-A7AF-EB02E69CB61A Q36389578-6012C8B1-B8B9-4249-A751-4D96CDCE3175 Q36495170-276F1FAE-25C4-44D0-9614-563CDFCC5D35 Q36548335-C6C2288E-6881-4A76-8918-0292B3D5642C Q36725098-669D3A8B-1729-4502-AEFC-D358A8846F6B Q37120958-35507A1D-E323-467B-81F7-84F61320F602 Q37122929-2E8C3E6F-9EE9-4C7C-9E2B-F263015F0E2B Q37224297-EE3BA649-3397-41E9-99AC-78DEDEA32910 Q37544748-799EA417-B0DB-4D67-835F-DD643F862D1C Q37601383-03F3FAA8-C8F0-4302-B70A-CE50CC36F8BA Q37603840-F0E83E4B-41BC-4E58-8EBF-0CFE000437AE Q37695433-B1DAF5A8-F32C-4238-95AC-CFF3D6634DC4 Q37957006-456AB50A-3546-4F32-BB58-8BC27EF78402 Q37969685-E908A0D0-E2F9-40A7-8EAF-E94F5118F29F Q38020424-B4BC4D7F-416F-4C8B-B062-CA67DDD5BE90 Q38051409-6748D97C-4DBD-4B1E-A986-43232C3171BB Q38103230-A9B8077E-1B1B-4CF2-95D3-0525CB541632 Q38121288-2F93266F-3A2A-41BF-B619-0793B1917D32

P2860

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

http://www.wikidata.org/entity/Q35170918

description

2011 nî lūn-bûn

@nan

2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Loss of the retinoblastoma bin ...... is in mice lacking Rb1 or Men1

@ast

Loss of the retinoblastoma bin ...... is in mice lacking Rb1 or Men1

@en

type

label

Loss of the retinoblastoma bin ...... is in mice lacking Rb1 or Men1

@ast

Loss of the retinoblastoma bin ...... is in mice lacking Rb1 or Men1

@en

prefLabel

Loss of the retinoblastoma bin ...... is in mice lacking Rb1 or Men1

@ast

Loss of the retinoblastoma bin ...... is in mice lacking Rb1 or Men1

@en

P1433

Q35170918-0EB087C0-41B2-4A86-96A4-342DB0C06D5C

P1476

Q35170918-3055A8AE-0A14-4A22-814E-75F42E8FE099

P2093

Q35170918-048DA17E-FD45-46FA-880C-33EA51645C53

Q35170918-2EA5472E-F644-4339-8B34-39B8F2C6A82D

Q35170918-42FD5151-F6A7-478A-B396-51857801EDF4

Q35170918-4C794007-D5CC-47CB-A782-B8ADD820A909

Q35170918-58D0B095-503F-45C5-8077-A6DB258B7944

Q35170918-6729C533-FCA6-4885-A335-FB8FEA03DB8D

Q35170918-72766F1A-A8FC-4C4D-86BD-56542A4C2BEA

Q35170918-76DAA736-C148-4205-ADDB-CFE32E3C8C11

Q35170918-8769E7B5-6680-463D-9F35-1EFEC350C637

Q35170918-97C79DD4-14BF-4CA1-98D0-3B037F640ADF

P2860

Q35170918-04DBC53D-9396-4695-A2AE-F72720A71ACC

Q35170918-06570FF9-135E-4118-8A06-A3C067E92317

Q35170918-098273C2-DFEC-46DA-A78E-A877B1AC9460

Q35170918-09F84441-09A9-40B9-B338-4D52383427F2

Q35170918-0D7588FF-DD48-4738-AC46-F0723D66957D

Q35170918-140671A8-A090-4CDD-BD2E-9F471F6D8786

Q35170918-157345E5-4BA4-4A89-B14F-50DBF6683A75

Q35170918-1F2390AD-0CB8-4CF9-BFEB-81EBBF23E866

Q35170918-24000EE2-B9FF-4F9A-B4DD-9C7816E6E507

Q35170918-2413A04F-9F9E-4FFC-ABA2-11F5520D24A4

P304

Q35170918-693A28DF-B13B-4B5C-9490-214D80D64767

P31

Q35170918-ABC8EFC9-430C-44D5-BF9B-5F85645A98AB

P356

Q35170918-0C6BE601-06C1-4A14-AA32-44768743AA4C

P407

Q35170918-9946C1C9-8D6C-40B8-9F80-51D4C4297E7A

P433

Q35170918-4F95ADB6-9D90-4B14-A0B2-756F6C4C8E52

P478

Q35170918-8C3F47D3-78BD-48CF-8CE9-6098B424C664

P50

Q35170918-0C22CD91-9247-4878-9D51-CD7CAFFB4CDB

Q35170918-58EC5A64-0F7A-4F59-9D84-CB8A1748EE1E

Q35170918-FC2E78BD-1397-4B0A-A41D-7F6BCD1BF6FF

P577

Q35170918-62E68C3E-DECA-435F-A4D2-D2AB31FE8A9E

P5875

Q35170918-B71A2CE3-4471-4793-8374-9D2C84BD8716

P698

Q35170918-FCCDBB33-D90D-431B-B785-C1A633124615

P921

Q35170918-8889F624-DB1B-4B4E-ADD0-849824E48FF3

P932

Q35170918-B68C68D9-6E32-40A2-93BF-114FB2E70EA6

P356

PNAS.1110104108

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Loss of the retinoblastoma bin ...... is in mice lacking Rb1 or Men1

@en

P2093

Andrew D Cherniack

http://www.w3.org/2001/XMLSchema#string

Chiara Grisanzio

http://www.w3.org/2001/XMLSchema#string

Christoph Geisen

http://www.w3.org/2001/XMLSchema#string

Dan Kawamori

http://www.w3.org/2001/XMLSchema#string

David P Tuck

http://www.w3.org/2001/XMLSchema#string

Elizaveta V Benevolenskaya

http://www.w3.org/2001/XMLSchema#string

Hideo Watanabe

http://www.w3.org/2001/XMLSchema#string

Jian Cao

http://www.w3.org/2001/XMLSchema#string

Jiayun Liu

http://www.w3.org/2001/XMLSchema#string

Joshua Francis

http://www.w3.org/2001/XMLSchema#string

P2860

A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases

JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

P304

13379-13386

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1110104108

http://www.w3.org/2001/XMLSchema#string

P407

P433

33

http://www.w3.org/2001/XMLSchema#string

P478

108

http://www.w3.org/2001/XMLSchema#string

P50

Yoji Andrew Minamishima

P577

2011-07-25T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51520560

http://www.w3.org/2001/XMLSchema#string

P698

21788502

http://www.w3.org/2001/XMLSchema#string

P921

P932

3158206

http://www.w3.org/2001/XMLSchema#string