mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.

mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.

Item
http://www.wikidata.org/entity/Q35182926
Organization of the ENaC-regulatory machineryA high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas.TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids.The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity.Target of rapamycin complex 2 signals to downstream effector yeast protein kinase 2 (Ypk2) through adheres-voraciously-to-target-of-rapamycin-2 protein 1 (Avo1) in Saccharomyces cerevisiae.mTORC2 critically regulates renal potassium handling.Regulation of ENaC in mice lacking renal insulin receptors in the collecting duct.Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit.Therapeutic potential of serum and glucocorticoid inducible kinase inhibition.mTOR controls kidney epithelia in health and disease.The TORC2-Dependent Signaling Network in the Yeast Saccharomyces cerevisiae.Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression.
P2860

mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.

Item
http://www.wikidata.org/entity/Q35182926
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
mSIN1 protein mediates SGK1 pr ...... the epithelial sodium channel.
@ast
mSIN1 protein mediates SGK1 pr ...... the epithelial sodium channel.
@en
type
label
mSIN1 protein mediates SGK1 pr ...... the epithelial sodium channel.
@ast
mSIN1 protein mediates SGK1 pr ...... the epithelial sodium channel.
@en
prefLabel
mSIN1 protein mediates SGK1 pr ...... the epithelial sodium channel.
@ast
mSIN1 protein mediates SGK1 pr ...... the epithelial sodium channel.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932
P356
P1433
P1476
mSIN1 protein mediates SGK1 pr ...... the epithelial sodium channel.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932