Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.
about
p53 regulation of G(2) checkpoint is retinoblastoma protein dependentHepatitis C Virus Induces E6AP-Dependent Degradation of the Retinoblastoma ProteinAccumulation of human papillomavirus type 16 E7 protein bypasses G1 arrest induced by serum deprivation and by the cell cycle inhibitor p21The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.The human papillomavirus type 58 E7 oncoprotein modulates cell cycle regulatory proteins and abrogates cell cycle checkpoints.Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway.Anchorage-independent transcription of the cyclin A gene induced by the E7 oncoprotein of human papillomavirus type 16.Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesisLow- and high-risk human papillomavirus E7 proteins regulate p130 differentlyDestabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes.Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis.Examination of the pRb-dependent and pRb-independent functions of E7 in vivo.E2F-Rb complexes assemble and inhibit cdc25A transcription in cervical carcinoma cells following repression of human papillomavirus oncogene expressionClinical and scientific impact of human papillomavirus on head and neck cancer.Disruption of the G1/S transition in human papillomavirus type 16 E7-expressing human cells is associated with altered regulation of cyclin EHuman papillomavirus oncoproteins E6 and E7 independently abrogate the mitotic spindle checkpoint.Human papillomavirus infections: epidemiology, pathogenesis, and therapy.Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradationImmortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7.p53-dependent growth arrest of REF52 cells containing newly amplified DNA.Biological activities and molecular targets of the human papillomavirus E7 oncoprotein.Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein.HPV16-E7 expression causes fluorodeoxyuridine-mediated radiosensitization in SW620 human colon cancer cells.Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivoTargeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization.Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer.Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways.Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutantAbrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation.Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoproteinPerturbation of the p53 response by human papillomavirus type 16 E7.Initiation of DNA synthesis by human papillomavirus E7 oncoproteins is resistant to p21-mediated inhibition of cyclin E-cdk2 activityHuman cytomegalovirus IE2 86-kilodalton protein binds p53 but does not abrogate G1 checkpoint function.Both conserved region 1 (CR1) and CR2 of the human papillomavirus type 16 E7 oncogene are required for induction of epidermal hyperplasia and tumor formation in transgenic mice.Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways.Co-regulation of p16INK4A and migratory genes in culture conditions that lead to premature senescence in human keratinocytes.Role of Cdk1 in DNA damage-induced G1 checkpoint abrogation by the human papillomavirus E7 oncogene.Suppression of p53 function in normal human mammary epithelial cells increases sensitivity to extracellular matrix-induced apoptosispRB plays an essential role in cell cycle arrest induced by DNA damage
P2860
Q22254140-55B3211E-5CDB-4B26-A9F4-3D55A7FF447AQ27485880-ADED3275-2C77-4519-A421-6A37598A46C7Q28775705-DAFF520C-BF40-4038-8714-7E1D90231BBAQ33292423-500999E6-0C93-4C49-A63D-8AB84F7D37A5Q33638499-8C466E96-78C2-4140-B9A5-C93461A56338Q33752967-211739CB-0C68-4B9C-810D-7919244EB7ACQ33782472-BE4CD05B-44DE-4FD9-90DE-FB58388564AFQ33805184-473385A7-0DE1-40AF-BF35-422CE769759EQ33819744-9444697A-A246-46A6-B42F-44163CB0C905Q33844017-EECE37CF-61C8-4E6F-9135-41498538C421Q33879990-C33ABA8A-2F6F-41EA-BFB7-46E52CDF460BQ33930412-E24F307C-B839-4AFA-883C-88BFDB56D23FQ33965671-5A2E32C3-1608-4423-9136-0F10CB367C2FQ34031281-23424DF1-B6DD-4113-A29B-4316364A6AE9Q34069083-528E7548-7378-44E9-AF7D-E39C8FBACA34Q34069364-421471E2-4106-475F-BE2A-8BC08D58434DQ34204141-1D49FFC4-8534-4FA0-ABB0-3AC3C8540577Q34223352-67123981-2819-433B-9152-69375DED72D3Q34249834-BE7AF1B6-C866-4FE7-A213-4F2B56B561E3Q34368179-D65F17CE-25C9-4401-95A9-F978C8FFF369Q34424487-F00217A1-A354-46FF-A959-50E5851AED4EQ34468787-9823917B-DA51-46E6-85C5-18E9DA9778DDQ34742793-BE1BF8FD-006D-4B84-A929-71DEEBBAE4A9Q34786268-1604835A-2690-48E0-A22B-2EF9F3DB879CQ34987709-427BB303-82B9-455B-AB69-862FD60C0E00Q35207910-B6436088-9A8C-4503-ADBE-A1609A7E7D03Q35576670-9C5451EE-685E-4614-9F10-A1871405A6D4Q35815917-2794599C-E6FC-4D75-AF6F-3B5CBA8DBC7CQ35853206-FF5F6C00-1767-4DC5-80C7-FE5EEBA30361Q35870318-22F1DED9-E374-4358-8624-FE3837515575Q35880696-F457DD79-D188-46C6-8F8F-4D79995AD3A8Q35883128-78EA6102-DF8A-4EF4-926D-3BE7D2D48759Q35888709-8CCADBEA-2B30-4374-BA0C-22140F93D0DBQ35889716-11387752-AA92-4BBB-816F-85C843D31354Q35889851-9AD2260A-0B30-45A9-B68A-32B3FD79DB28Q35912299-5E80FDCC-B3AE-440B-866E-3B09A103CB1EQ36063670-452066B6-D812-428F-B65F-E7B5A457512FQ36187434-B80A3E40-C787-45A6-A1DF-703EC318D3E8Q36294095-CE4006A2-BC04-43EB-BDAB-966193683F61Q36326866-125BF009-9F26-4518-8F92-E8A6A234A119
P2860
Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.
description
1994 nî lūn-bûn
@nan
1994 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Growth arrest by induction of ...... by human papillomavirus 16 E7.
@ast
Growth arrest by induction of ...... by human papillomavirus 16 E7.
@en
type
label
Growth arrest by induction of ...... by human papillomavirus 16 E7.
@ast
Growth arrest by induction of ...... by human papillomavirus 16 E7.
@en
prefLabel
Growth arrest by induction of ...... by human papillomavirus 16 E7.
@ast
Growth arrest by induction of ...... by human papillomavirus 16 E7.
@en
P2093
P2860
P356
P1476
Growth arrest by induction of ...... by human papillomavirus 16 E7.
@en
P2093
Galloway DA
Halbert CL
P2860
P304
P356
10.1073/PNAS.91.10.4382
P407
P577
1994-05-01T00:00:00Z