Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.
about
Mitochondrial diseases caused by toxic compound accumulation: from etiopathology to therapeutic approachesA Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development.Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S PhaseProgerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes.S phase block following MEC1ATR inactivation occurs without severe dNTP depletion.Heterozygous colon cancer-associated mutations of SAMHD1 have functional significanceA Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR InhibitorsThe essential kinase ATR: ensuring faithful duplication of a challenging genome.DNA replication stress: from molecular mechanisms to human disease.S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion.The Role of the Transcriptional Response to DNA Replication Stress.Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress.p53R2 overexpression in cervical cancer promotes AKT signaling and EMT, and is correlated with tumor progression, metastasis and poor prognosis.Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1.An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability.Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place.
P2860
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P2860
Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.
description
2015 nî lūn-bûn
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2015 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Increased Rrm2 gene dosage red ...... s survival of ATR mutant mice.
@ast
Increased Rrm2 gene dosage red ...... s survival of ATR mutant mice.
@en
type
label
Increased Rrm2 gene dosage red ...... s survival of ATR mutant mice.
@ast
Increased Rrm2 gene dosage red ...... s survival of ATR mutant mice.
@en
prefLabel
Increased Rrm2 gene dosage red ...... s survival of ATR mutant mice.
@ast
Increased Rrm2 gene dosage red ...... s survival of ATR mutant mice.
@en
P2093
P2860
P50
P356
P1433
P1476
Increased Rrm2 gene dosage red ...... s survival of ATR mutant mice.
@en
P2093
André Nussenzweig
Henrik Green
Jacqueline H Barlow
Julia Specks
Matilde Murga
Sara Rodrigo-Perez
Svante Vikingsson
P2860
P304
P356
10.1101/GAD.256958.114
P577
2015-04-01T00:00:00Z