Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.
about
DUBs, New Members in the Hypoxia Signaling clUbHypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and TransactivityTargeting the ubiquitin pathway for cancer treatmentGenetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroidsAberrant regulation of FBW7 in cancer.Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancerThe archipelago ubiquitin ligase subunit acts in target tissue to restrict tracheal terminal cell branching and hypoxic-induced gene expression.A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cellsTumor suppressor functions of FBW7 in cancer development and progression.Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy.The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness.MiR-182 promotes proliferation and invasion and elevates the HIF-1α-VEGF-A axis in breast cancer cells by targeting FBXW7Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling.Hypoxic inactivation of glycogen synthase kinase-3β promotes gastric tumor growth and angiogenesis by facilitating hypoxia-inducible factor-1 signaling.Recent advances in SCF ubiquitin ligase complex: Clinical implicationsFBW7 increases drug sensitivity to cisplatin in human nasopharyngeal carcinoma by downregulating the expression of multidrug resistance-associated protein.Direct phosphorylation events involved in HIF-α regulation: the role of GSK-3β.Assessing the effects of threonyl-tRNA synthetase on angiogenesis-related responses.F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation.Bcl-2 family member Mcl-1 expression is reduced under hypoxia by the E3 ligase FBW7 contributing to BNIP3 induced cell death in glioma cellsSecreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis.F-box proteins in epigenetic regulation of cancer.Physiological functions of FBW7 in cancer and metabolism.Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System
P2860
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P2860
Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.
@ast
Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.
@en
type
label
Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.
@ast
Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.
@en
prefLabel
Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.
@ast
Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.
@en
P2093
P2860
P356
P1476
Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.
@en
P2093
Alan K Howe
Cheung Wong
Jessica M Cassavaugh
Karen M Lounsbury
Sarah A Hale
Theresa L Wellman
P2860
P304
P356
10.1002/JCB.23321
P577
2011-12-01T00:00:00Z