Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia. - Test2 - elhamkhani - TriplyDB

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.

http://www.wikidata.org/entity/Q35449110

about

DUBs, New Members in the Hypoxia Signaling clUb Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity Targeting the ubiquitin pathway for cancer treatment Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids Aberrant regulation of FBW7 in cancer.Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer The archipelago ubiquitin ligase subunit acts in target tissue to restrict tracheal terminal cell branching and hypoxic-induced gene expression.A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells Tumor suppressor functions of FBW7 in cancer development and progression.Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy.The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness.MiR-182 promotes proliferation and invasion and elevates the HIF-1α-VEGF-A axis in breast cancer cells by targeting FBXW7 Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling.Hypoxic inactivation of glycogen synthase kinase-3β promotes gastric tumor growth and angiogenesis by facilitating hypoxia-inducible factor-1 signaling.Recent advances in SCF ubiquitin ligase complex: Clinical implications FBW7 increases drug sensitivity to cisplatin in human nasopharyngeal carcinoma by downregulating the expression of multidrug resistance-associated protein.Direct phosphorylation events involved in HIF-α regulation: the role of GSK-3β.Assessing the effects of threonyl-tRNA synthetase on angiogenesis-related responses.F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation.Bcl-2 family member Mcl-1 expression is reduced under hypoxia by the E3 ligase FBW7 contributing to BNIP3 induced cell death in glioma cells Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis.F-box proteins in epigenetic regulation of cancer.Physiological functions of FBW7 in cancer and metabolism.Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System

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P2860

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.

http://www.wikidata.org/entity/Q35449110

description

2011 nî lūn-bûn

@nan

2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.

@ast

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.

@en

type

label

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.

@ast

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.

@en

prefLabel

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.

@ast

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.

@en

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P1433

Journal of Cellular Biochemistry

P1476

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia.

@en

P2093

Alan K Howe

http://www.w3.org/2001/XMLSchema#string

Cheung Wong

http://www.w3.org/2001/XMLSchema#string

Jessica M Cassavaugh

http://www.w3.org/2001/XMLSchema#string

Karen M Lounsbury

http://www.w3.org/2001/XMLSchema#string

Sarah A Hale

http://www.w3.org/2001/XMLSchema#string

Theresa L Wellman

http://www.w3.org/2001/XMLSchema#string

P2860

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase

AKT/PKB signaling: navigating downstream

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases

beta-catenin is a target for the ubiquitin-proteasome pathway

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

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3882-3890

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scholarly article

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10.1002/JCB.23321

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12

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112

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2011-12-01T00:00:00Z

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51688273

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21964756

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P932

3202039

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