Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy.
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SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradationThe antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stressProtein Folding and Mechanisms of ProteostasisHigh-throughput transcriptomic and RNAi analysis identifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancerDisulfide bond disrupting agents activate the unfolded protein response in EGFR- and HER2-positive breast tumor cells.Ritonavir and ixazomib kill bladder cancer cells by causing ubiquitinated protein accumulation.The final moments of misfolded proteins en route to the proteasome.Protein mislocalization: mechanisms, functions and clinical applications in cancer.Panobinostat synergizes with bortezomib to induce endoplasmic reticulum stress and ubiquitinated protein accumulation in renal cancer cells.Cross-presentation of synthetic long peptides by human dendritic cells: a process dependent on ERAD component p97/VCP but Not sec61 and/or Derlin-1.The human immunodeficiency virus protease inhibitor ritonavir is potentially active against urological malignancies.Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cellsDisturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells.Vorinostat approved in Japan for treatment of cutaneous T-cell lymphomas: status and prospects.EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanismBortezomib and belinostat inhibit renal cancer growth synergistically by causing ubiquitinated protein accumulation and endoplasmic reticulum stress.gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulumRoles of p97-associated deubiquitinases in protein quality control at the endoplasmic reticulumIcariin displays anticancer activity against human esophageal cancer cells via regulating endoplasmic reticulum stress-mediated apoptotic signaling.Phosphorylation of serine palmitoyltransferase long chain-1 (SPTLC1) on tyrosine 164 inhibits its activity and promotes cell survival.Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse modelThapsigargin sensitizes human esophageal cancer to TRAIL-induced apoptosis via AMPK activation.Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells.Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation.Mechanisms of proteasome inhibitor-induced cytotoxicity in malignant glioma.Proteostasis in endoplasmic reticulum--new mechanisms in kidney disease.Divergent androgen regulation of unfolded protein response pathways drives prostate cancer.Review and Literature Mining on Proteostasis Factors and Cancer.The unfolded protein response selectively targets active smoothened mutants.Luminescent organoplatinum(II) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity.Glycosylated copper(II) ionophores as prodrugs for β-glucosidase activation in targeted cancer therapy.Resistance to paclitxel in breast carcinoma cells requires a quality control of mitochondrial antiapoptotic proteins by TRAP1.In silico analysis and developmental expression of ubiquitin-conjugating enzymes in Schistosoma mansoni.High TXNDC5 expression predicts poor prognosis in renal cell carcinoma.
P2860
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P2860
Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Proteostasis regulation at the ...... e for targeted cancer therapy.
@ast
Proteostasis regulation at the ...... e for targeted cancer therapy.
@en
type
label
Proteostasis regulation at the ...... e for targeted cancer therapy.
@ast
Proteostasis regulation at the ...... e for targeted cancer therapy.
@en
prefLabel
Proteostasis regulation at the ...... e for targeted cancer therapy.
@ast
Proteostasis regulation at the ...... e for targeted cancer therapy.
@en
P2860
P356
P1433
P1476
Proteostasis regulation at the ...... e for targeted cancer therapy.
@en
P2093
P2860
P2888
P304
P356
10.1038/CR.2011.75
P577
2011-05-03T00:00:00Z