ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
about
Cross talk of tyrosine kinases with the DNA damage signaling pathwaysThe Role of MicroRNAs as Predictors of Response to Tamoxifen Treatment in Breast Cancer PatientsRegulation of Multi-drug Resistance in hepatocellular carcinoma cells is TRPC6/Calcium Dependent.Development of novel ACK1/TNK2 inhibitors using a fragment-based approachA dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACKActivated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic AnalysisAck1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma.Racial differences in genome-wide methylation profiling and gene expression in breast tissues from healthy womenAck promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded.APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment.Novel multiple tyrosine kinase inhibitor ponatinib inhibits bFGF-activated signaling in neuroblastoma cells and suppresses neuroblastoma growth in vivo.Amplification of ACK1 promotes gastric tumorigenesis via ECD-dependent p53 ubiquitination degradation.The non-receptor tyrosine kinase TNK2/ACK1 is a novel therapeutic target in triple negative breast cancer.ACK1 promotes gastric cancer epithelial-mesenchymal transition and metastasis through AKT-POU2F1-ECD signalling.Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms.WEE1 epigenetically modulates 5-hmC levels by pY37-H2B dependent regulation of IDH2 gene expression.Blockade of ACK1/TNK2 To Squelch the Survival of Prostate Cancer Stem-like Cells.Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products.Ceritinib Enhances the Efficacy of Trametinib in BRAF/NRAS-Wild-Type Melanoma Cell Lines.ACK1/TNK2 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer.Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer.Histone deacetylase inhibitors induce proteolysis of activated CDC42-associated kinase-1 in leukemic cells.Major Physiological Signaling Pathways in the Regulation of Cell Proliferation and Survival.Genome-wide linkage analysis in Spanish melanoma-prone families identifies a new familial melanoma susceptibility locus at 11q
P2860
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P2860
ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
@ast
ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
@en
type
label
ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
@ast
ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
@en
prefLabel
ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
@ast
ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
@en
P2860
P921
P356
P1433
P1476
ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
@en
P2093
N P Mahajan
P2860
P2888
P304
P356
10.1038/ONC.2014.350
P407
P577
2014-10-27T00:00:00Z
2015-08-06T00:00:00Z