Runx1 loss minimally impacts long-term hematopoietic stem cells - Test2 - elhamkhani - TriplyDB

Runx1 loss minimally impacts long-term hematopoietic stem cells

Runx1 loss minimally impacts long-term hematopoietic stem cells

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Transcription factor-mediated reprogramming toward hematopoietic stem cells Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors.Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder.NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis.RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice.The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis.Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome Runx1 Phosphorylation by Src Increases Trans-activation via Augmented Stability, Reduced Histone Deacetylase (HDAC) Binding, and Increased DNA Affinity, and Activated Runx1 Favors Granulopoiesis Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations.A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation Targeting binding partners of the CBFβ-SMMHC fusion protein for the treatment of inversion 16 acute myeloid leukemia.A role for RUNX1 in hematopoiesis and myeloid leukemia.Runx Family Genes in Tissue Stem Cell Dynamics.Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells.RUNX1 cooperates with FLT3-ITD to induce leukemia.The transcriptional programme controlled by Runx1 during early embryonic blood development.Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs.Tyrosyl phosphorylation toggles a Runx1 switch.Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells.A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells.RUNX1 Mutations in Inherited and Sporadic Leukemia.Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach

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Runx1 loss minimally impacts long-term hematopoietic stem cells

http://www.wikidata.org/entity/Q35586823

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

@zh-cn

name

Runx1 loss minimally impacts long-term hematopoietic stem cells

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Runx1 loss minimally impacts long-term hematopoietic stem cells

@en

type

label

Runx1 loss minimally impacts long-term hematopoietic stem cells

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Runx1 loss minimally impacts long-term hematopoietic stem cells

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prefLabel

Runx1 loss minimally impacts long-term hematopoietic stem cells

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Runx1 loss minimally impacts long-term hematopoietic stem cells

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JOURNAL.PONE.0028430

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Runx1 loss minimally impacts long-term hematopoietic stem cells

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James K Mangan

http://www.w3.org/2001/XMLSchema#string

Justin J Gaudet

http://www.w3.org/2001/XMLSchema#string

Maria Elena De Obaldia

http://www.w3.org/2001/XMLSchema#string

Michael J Chen

http://www.w3.org/2001/XMLSchema#string

Nancy A Speck

http://www.w3.org/2001/XMLSchema#string

Xiongwei Cai

http://www.w3.org/2001/XMLSchema#string

Zaw Oo

http://www.w3.org/2001/XMLSchema#string

P2860

NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1

RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group.

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

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e28430

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scholarly article

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10.1371/JOURNAL.PONE.0028430

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12

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2011-12-01T00:00:00Z

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51856041

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22145044

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3228772

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