about
Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localizationMLL and CREB bind cooperatively to the nuclear coactivator CREB-binding proteinThe lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros geneDown-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activatorNeuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memoryMLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.Embryonic stem cell-derived hematopoietic stem cells.WRAD: enabler of the SET1-family of H3K4 methyltransferases.Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Runx1 loss minimally impacts long-term hematopoietic stem cellsMLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemiaMammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic developmentAn MLL-dependent network sustains hematopoiesis.Leukemia and hematopoietic stem cells: balancing proliferation and quiescence.Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cellsAcat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis.Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets.Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene.Distinct functions of histone H3, lysine 4 methyltransferases in normal and malignant hematopoiesis.SET/MLL family proteins in hematopoiesis and leukemia.NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.A potential role for Elf-1 in terminal transferase gene regulationCombinatorial regulation of transcription. I: General aspects of transcriptional control.Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene.cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes.The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesisIFN-alpha wakes up sleeping hematopoietic stem cells.Cell context in the control of self-renewal and proliferation regulated by MLL1.Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety.MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation.Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL-AF9-Initiated Leukemia.Harnessing gene repression to inhibit leukemiaHematopoietic transformation in the absence of MLL1/KMT2A: distinctions in target gene reactivation
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onderzoeker
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researcher
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հետազոտող
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P Ernst
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P Ernst
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P Ernst
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P Ernst
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P Ernst
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P Ernst
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P Ernst
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P Ernst
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P Ernst
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P Ernst
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P Ernst
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P Ernst
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P Ernst
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P Ernst
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P Ernst
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P106
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7101681075
P31
P496
0000-0001-7638-2939