Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.
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Ubiquitin modificationsUbiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatmentExpanding the ubiquitin code through post-translational modificationEndogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic StressProbes of ubiquitin E3 ligases enable systematic dissection of parkin activationStructural insights into Parkin substrate lysine targeting from minimal Miro substratesStructure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation.The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote MitophagyA Ubl/ubiquitin switch in the activation of ParkinThe ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradationPhosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.Abnormal Development of Glutamatergic Synapses Afferent to Dopaminergic Neurons of the Pink1(-/-) Mouse Model of Parkinson's Disease.The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.Gold nanoparticles enhance TRAIL sensitivity through Drp1-mediated apoptotic and autophagic mitochondrial fission in NSCLC cellsA PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.Recent advances in quantitative and chemical proteomics for autophagy studies.Highly Multiplexed Quantitative Mass Spectrometry Analysis of Ubiquitylomes.Central Parkin: The evolving role of Parkin in the heart.Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.The increasing complexity of the ubiquitin code.Structural insights into the catalysis and regulation of E3 ubiquitin ligases.Parkin and mitophagy in cancer.Altered mitochondrial dynamics as a consequence of Venezuelan Equine encephalitis virus infection.Parkin and PINK1 functions in oxidative stress and neurodegeneration.Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases.Integrating the UPRmt into the mitochondrial maintenance network.Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury.Ubiquitin and Parkinson's disease through the looking glass of genetics.Viral deubiquitinases: role in evasion of anti-viral innate immunity.Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bit.How phosphoubiquitin activates Parkin.Subunit-Specific Labeling of Ubiquitin Chains by Using Sortase: Insights into the Selectivity of Deubiquitinases.Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.Mechanism of phospho-ubiquitin-induced PARKIN activation.Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects.Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria.
P2860
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P2860
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Defining roles of PARKIN and u ...... biquitin replacement strategy.
@ast
Defining roles of PARKIN and u ...... biquitin replacement strategy.
@en
type
label
Defining roles of PARKIN and u ...... biquitin replacement strategy.
@ast
Defining roles of PARKIN and u ...... biquitin replacement strategy.
@en
prefLabel
Defining roles of PARKIN and u ...... biquitin replacement strategy.
@ast
Defining roles of PARKIN and u ...... biquitin replacement strategy.
@en
P2093
P2860
P50
P356
P1476
Defining roles of PARKIN and u ...... ubiquitin replacement strategy
@en
P2093
David M Duda
David Yanishevski
Jennifer L Olszewski
Jesse Rinehart
Jin-Mi Heo
Joao A Paulo
P2860
P304
P356
10.1073/PNAS.1506593112
P407
P577
2015-05-12T00:00:00Z