The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function.
about
Readers of poly(ADP-ribose): designed to be fit for purposeA first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain constructStructural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complexp38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damageOverlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin.Coordination of DNA single strand break repair.PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2)The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair.Triptolide induces DNA breaks, activates caspase-3-dependent apoptosis and sensitizes B-cell lymphoma to poly(ADP-ribose) polymerase 1 and phosphoinositide 3-kinase inhibitors.Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.Characterization of the APLF FHA-XRCC1 phosphopeptide interaction and its structural and functional implications.Meta-analysis of DNA double-strand break response kinetics.Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication
P2860
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P2860
The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function.
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
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2015年论文
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name
The XRCC1 phosphate-binding po ...... s required for XRCC1 function.
@ast
The XRCC1 phosphate-binding po ...... s required for XRCC1 function.
@en
type
label
The XRCC1 phosphate-binding po ...... s required for XRCC1 function.
@ast
The XRCC1 phosphate-binding po ...... s required for XRCC1 function.
@en
prefLabel
The XRCC1 phosphate-binding po ...... s required for XRCC1 function.
@ast
The XRCC1 phosphate-binding po ...... s required for XRCC1 function.
@en
P2093
P2860
P356
P1476
The XRCC1 phosphate-binding po ...... s required for XRCC1 function.
@en
P2093
Andrew Ridley
Claire Breslin
Keith W Caldecott
Peter Hornyak
Stuart L Rulten
P2860
P304
P356
10.1093/NAR/GKV623
P407
P577
2015-06-29T00:00:00Z