Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus
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LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in miceSTAT5a/b contribute to sex bias in vascular disease: A neuroendocrine perspectiveSexually dimorphic genome-wide binding of retinoid X receptor alpha (RXRα) determines male-female differences in the expression of hepatic lipid processing genes in miceThe liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice.Hepatocyte expression of serum response factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in miceIn vivo targeting of the growth hormone receptor (GHR) Box1 sequence demonstrates that the GHR does not signal exclusively through JAK2.Intrinsic sex differences in the early growth hormone responsiveness of sex-specific genes in mouse liverVitamin B₁₂-dependent taurine synthesis regulates growth and bone mass.Minireview: mechanisms of growth hormone-mediated gene regulation.Sex-specific gene expression in the BXD mouse liverUnbiased, genome-wide in vivo mapping of transcriptional regulatory elements reveals sex differences in chromatin structure associated with sex-specific liver gene expressionAlterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alphaIncreased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice.Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2.Context-Specific Growth Hormone Signaling through the Transcription Factor STAT5: Implications for the Etiology of Hepatosteatosis and Hepatocellular Carcinoma.The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expressionDeletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice.Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liverDisruption of STAT5b-Regulated Sexual Dimorphism of the Liver Transcriptome by Diverse Factors Is a Common EventThe intricate role of growth hormone in metabolism.Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism.Hepatic Long Intergenic Noncoding RNAs: High Promoter Conservation and Dynamic, Sex-Dependent Transcriptional Regulation by Growth Hormone.Hypothesis: neuroendocrine mechanisms (hypothalamus-growth hormone-STAT5 axis) contribute to sex bias in pulmonary hypertension.Nuclear receptor CAR specifically activates the two-pore K+ channel Kcnk1 gene in male mouse livers, which attenuates phenobarbital-induced hepatic hyperplasia.Liver-specific hepatocyte nuclear factor-4alpha deficiency: greater impact on gene expression in male than in female mouse liver.Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns.Genomic dissection of the cytokine-controlled STAT5 signaling network in liverInhibition of growth hormone signaling by the fasting-induced hormone FGF21.Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturationMechanism of gender-divergent UDP-glucuronosyltransferase mRNA expression in mouse liver and kidney.Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genesSex differences in the expression of hepatic drug metabolizing enzymes.Dynamic in vivo binding of STAT5 to growth hormone-regulated genes in intact rat liver. Sex-specific binding at low- but not high-affinity STAT5 sites.Sex-specific early growth hormone response genes in rat liver.Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5Differential cytokine sensitivities of STAT5-dependent enhancers rely on Stat5 autoregulation.Increased SULT1E1 activity in HepG2 hepatocytes decreases growth hormone stimulation of STAT5b phosphorylation.Feminization of male mouse liver by persistent growth hormone stimulation: Activation of sex-biased transcriptional networks and dynamic changes in chromatin states.
P2860
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P2860
Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Loss of sexually dimorphic liv ...... eletion of Stat5a-Stat5b locus
@ast
Loss of sexually dimorphic liv ...... eletion of Stat5a-Stat5b locus
@en
type
label
Loss of sexually dimorphic liv ...... eletion of Stat5a-Stat5b locus
@ast
Loss of sexually dimorphic liv ...... eletion of Stat5a-Stat5b locus
@en
prefLabel
Loss of sexually dimorphic liv ...... eletion of Stat5a-Stat5b locus
@ast
Loss of sexually dimorphic liv ...... eletion of Stat5a-Stat5b locus
@en
P2093
P2860
P356
P1433
P1476
Loss of sexually dimorphic liv ...... eletion of Stat5a-Stat5b locus
@en
P2093
Atsushi Hosui
Ekaterina V Laz
Minita G Holloway
Yongzhi Cui
P2860
P304
P356
10.1210/EN.2006-1419
P407
P577
2007-02-22T00:00:00Z