Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
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Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cellsEpigenetics and agingHypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related DiseasesEpigenetic modulators, modifiers and mediators in cancer aetiology and progressionProgramming and Reprogramming Cellular Age in the Era of Induced PluripotencyWerner syndrome: Clinical features, pathogenesis and potential therapeutic interventionsQuantitative Immunofluorescence Analysis of Nucleolus-Associated ChromatinRepression of the Antioxidant NRF2 Pathway in Premature AgingVisualization of aging-associated chromatin alterations with an engineered TALE system.Genome engineering of stem cell organoids for disease modeling.CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs.Accelerated epigenetic aging in Werner syndromeNucleolus association of chromosomal domains is largely maintained in cellular senescence despite massive nuclear reorganisation.In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCsStem cell aging in adult progeria.Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria SyndromePTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotypeGIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging.Epigenetic regulation of ageing: linking environmental inputs to genomic stability.SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus.DNA double strand break repair, aging and the chromatin connection.KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.The Aging EpigenomeEvolution of Microbial Quorum Sensing to Human Global Quorum Sensing: An Insight into How Gap Junctional Intercellular Communication Might Be Linked to the Global Metabolic Disease Crisis.Vitamin C alleviates aging defects in a stem cell model for Werner syndromeNovel regional age-associated DNA methylation changes within human common disease-associated lociThe Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription.WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational ProspectsDrug-induced premature senescence model in human dental follicle stem cells.FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging.The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.Oxidative stress in mesenchymal stem cell senescence: regulation by coding and non-coding RNAs.Stem cells and healthy aging.An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions.Class I Histone Deacetylase HDAC1 and WRN RECQ Helicase Contribute Additively to Protect Replication Forks upon Hydroxyurea-induced Arrest.SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence.New Insights into the Regulation of Heterochromatin.The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism.
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P2860
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Aging stem cells. A Werner syn ...... ns as a driver of human aging.
@ast
Aging stem cells. A Werner syn ...... ns as a driver of human aging.
@en
type
label
Aging stem cells. A Werner syn ...... ns as a driver of human aging.
@ast
Aging stem cells. A Werner syn ...... ns as a driver of human aging.
@en
prefLabel
Aging stem cells. A Werner syn ...... ns as a driver of human aging.
@ast
Aging stem cells. A Werner syn ...... ns as a driver of human aging.
@en
P2093
P2860
P356
P1433
P1476
Aging stem cells. A Werner syn ...... ns as a driver of human aging.
@en
P2093
Alejandro Ocampo
April Goebl
Chang Chen
Concepcion Rodriguez Esteban
Emi Aizawa
Fuchou Tang
Fuquan Yang
Guang-Hui Liu
P2860
P304
P356
10.1126/SCIENCE.AAA1356
P407
P577
2015-04-30T00:00:00Z