Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones. - Test2 - elhamkhani - TriplyDB

Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones.

Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones.

http://www.wikidata.org/entity/Q34088395

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CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes CRISPR-Cas9 Genome Editing in Drosophila The Rise of CRISPR/Cas for Genome Editing in Stem Cells Minimizing off-Target Mutagenesis Risks Caused by Programmable Nucleases Engineered Viruses as Genome Editing Devices Reprogramming cells with synthetic proteins Progress and prospects of engineered sequence-specific DNA modulating technologies for the management of liver diseases Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells Transcription activator-like effector nuclease (TALEN)-mediated CLYBL targeting enables enhanced transgene expression and one-step generation of dual reporter human induced pluripotent stem cell (iPSC) and neural stem cell (NSC) lines.The application of genome editing in studying hearing loss Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy.CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs.The CRISPR/Cas9 system efficiently reverts the tumorigenic ability of BCR/ABL in vitro and in a xenograft model of chronic myeloid leukemia.Induced Pluripotent Stem Cells: Global Research Trends.CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues.A CRISPR view of development.Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells.Mitochondrial replacement therapy in reproductive medicine.Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9 CRISPR/Cas9 and TALE: beyond cut and paste.Regenerative medicine: targeted genome editing in vivo.A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture.Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice.The iCRISPR platform for rapid genome editing in human pluripotent stem cells.Factor-induced Reprogramming and Zinc Finger Nuclease-aided Gene Targeting Cause Different Genome Instability in β-Thalassemia Induced Pluripotent Stem Cells (iPSCs).Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos.Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes Modeling developmental neuropsychiatric disorders with iPSC technology: challenges and opportunities Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing.Minireview: Genome Editing of Human Pluripotent Stem Cells for Modeling Metabolic Disease.Different Effects of sgRNA Length on CRISPR-mediated Gene Knockout Efficiency.Homology Requirements for Efficient, Footprintless Gene Editing at the CFTR Locus in Human iPSCs with Helper-dependent Adenoviral Vectors.Programmable Genome Editing Tools and their Regulation for Efficient Genome Engineering.Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells.Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9.Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming

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Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones.

http://www.wikidata.org/entity/Q34088395

description

2014 nî lūn-bûn

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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2014 թվականի հուլիսին հրատարակված գիտական հոդված

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2014年の論文

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Targeted gene correction minim ...... pluripotent stem cell clones.

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Targeted gene correction minim ...... pluripotent stem cell clones.

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Targeted gene correction minim ...... pluripotent stem cell clones.

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Targeted gene correction minim ...... pluripotent stem cell clones.

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Targeted gene correction minim ...... pluripotent stem cell clones.

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Targeted gene correction minim ...... pluripotent stem cell clones.

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Targeted gene correction minim ...... pluripotent stem cell clones.

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Targeted gene correction minim ...... pluripotent stem cell clones.

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Targeted gene correction minim ...... pluripotent stem cell clones.

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April Goebl

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Chang Yu

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Concepcion Rodriguez Esteban

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Emi Aizawa

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Fan Zhang

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Feng Chen

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Guang-Hui Liu

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Hsin-Kai Liao

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Jessica Kim

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Jing Qu

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P2860

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

The Catalogue of Somatic Mutations in Cancer (COSMIC)

Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy.

A method and server for predicting damaging missense mutations

Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection

Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity

Quantifying genome-editing outcomes at endogenous loci with SMRT sequencing.

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31-36

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10.1016/J.STEM.2014.06.016

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24996168

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Human Induced Pluripotent Stem Cells

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4144407

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