Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
about
Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodiesThe Progress of Induced Pluripotent Stem Cells as Models of Parkinson's DiseaseInduced pluripotent stem cells for modeling neurological disordersUsing iPS Cells toward the Understanding of Parkinson's DiseaseConcise review: Generation of neurons from somatic cells of healthy individuals and neurological patients through induced pluripotency or direct conversionProgramming and Reprogramming Cellular Age in the Era of Induced PluripotencySelf-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease PhenotypesFrom "directed differentiation" to "neuronal induction": modeling neuropsychiatric diseaseLRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectivesNon-coding RNA in neural function, disease, and agingReevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicismToward pluripotency by reprogramming: mechanisms and applicationGlobal DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes.Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegenerationVisualization of aging-associated chromatin alterations with an engineered TALE system.Solving the puzzle of Parkinson's disease using induced pluripotent stem cells.CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs.Mechanisms and consequences of aneuploidy and chromosome instability in the aging brainA novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation.Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones.Scientific progress regarding neural regeneration in the Web of Science: A 10-year bibliometric analysis.Hippocampal proliferation is increased in presymptomatic Parkinson's disease and due to microglia.Investigating human disease using stem cell models.Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplicationStem cells on the brain: modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells.Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCsModeling human neurological disorders with induced pluripotent stem cells.Clinical therapy using iPSCs: hopes and challengesA widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells.Advances in reprogramming-based study of neurologic disordersA computational approach to detect and segment cytoplasm in muscle fiber imagesProbing disorders of the nervous system using reprogramming approaches.Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos.Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCsLarge-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation.PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotypePINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes.SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons.
P2860
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P248
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P2860
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
@ast
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
@en
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
@en-gb
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
@nl
type
label
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
@ast
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
@en
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
@en-gb
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
@nl
prefLabel
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
@ast
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
@en
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
@en-gb
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
@en
P2093
April Goebl
Audrey Kim
Concepcion Rodriguez Esteban
Emmanuel Nivet
Guang-Hui Liu
Ilir Dubova
James Thompson
Jessica Kim
P2860
P2888
P3181
P356
10.1038/NATURE11557
P407
P577
2012-11-22T00:00:00Z
P5875
P6179
1025324656