Thermal proteome profiling monitors ligand interactions with cellular membrane proteins. - Test2 - elhamkhani - TriplyDB

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

http://www.wikidata.org/entity/Q35829229

about

The diverse and expanding role of mass spectrometry in structural and molecular biology Time, space, and disorder in the expanding proteome universe.Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.Identification of protein binding partners of small molecules using label-free methods.Label-free target identification using in-gel fluorescence difference via thermal stability shift.Thermal proteome profiling: unbiased assessment of protein state through heat-induced stability changes.In silico polypharmacology of natural products.Early Perspective.Detergents: Friends not foes for high-performance membrane proteomics toward precision medicine.Non-kinase targets of protein kinase inhibitors.Genome-Scale Architecture of Small Molecule Regulatory Networks and the Fundamental Trade-Off between Regulation and Enzymatic Activity.Mass spectrometry methods to study protein-metabolite interactions.Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat.Target engagement: Shining a light.A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.A high content, high throughput cellular thermal stability assay for measuring drug-target engagement in living cells.Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface.Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib.Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift.Thermal proteome profiling in bacteria: probing protein state Label-free technologies for target identification and validation Critical role for cholesterol in Lassa fever virus entry identified by a novel small molecule inhibitor targeting the viral receptor LAMP1

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Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

http://www.wikidata.org/entity/Q35829229

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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name

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

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Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

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type

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Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

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Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

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Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

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Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

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Thermal proteome profiling monitors ligand interactions with cellular membrane proteins

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Carola Doce

http://www.w3.org/2001/XMLSchema#string

Dorothee Childs

http://www.w3.org/2001/XMLSchema#string

Friedrich B M Reinhard

http://www.w3.org/2001/XMLSchema#string

Holger Franken

http://www.w3.org/2001/XMLSchema#string

Maria Fälth Savitski

http://www.w3.org/2001/XMLSchema#string

Mikhail M Savitski

http://www.w3.org/2001/XMLSchema#string

Thilo Werner

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Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

Crystal structure of the high-affinity Na+,K+-ATPase-ouabain complex with Mg2+ bound in the cation binding site

Inhibition ofMycobacterium tuberculosisTransaminase BioA by Aryl Hydrazines and Hydrazides

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

How many drug targets are there?

Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assays.

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors.

Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.

Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

Ion coalescence of neutron encoded TMT 10-plex reporter ions.

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1129-1131

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scholarly article

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10.1038/NMETH.3652

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12

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12

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Marcus Bantscheff

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2015-11-02T00:00:00Z

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26524241

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