NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells. - Test2 - elhamkhani - TriplyDB

NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells.

NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells.

http://www.wikidata.org/entity/Q35850681

about

The role of HDAC6 in cancer PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells Trial Watch: Proteasomal inhibitors for anticancer therapy Mechanisms of synergistic antileukemic interactions between valproic acid and cytarabine in pediatric acute myeloid leukemia Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors Discovery of novel proteasome inhibitors using a high-content cell-based screening system Proteasome inhibitors in glioblastoma Discovery and development of the anticancer agent salinosporamide A (NPI-0052).Oxidative stress by targeted agents promotes cytotoxicity in hematologic malignancies.Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib).Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules.Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage.Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides Antineoplastic effects of CPPTL via the ROS/JNK pathway in acute myeloid leukemia.Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.The ubiquitin-proteasome system: opportunities for therapeutic intervention in solid tumors Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity.Advances in and applications of proteasome inhibitors Proteasome inhibitors in cancer therapy In vitro and in vivo interactions between the HDAC6 inhibitor ricolinostat (ACY1215) and the irreversible proteasome inhibitor carfilzomib in non-Hodgkin lymphoma cells Proteasome inhibitor patents (2010 - present).Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8.Antioxidants impair anti-tumoral effects of Vorinostat, but not anti-neoplastic effects of Vorinostat and caspase-8 downregulation Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors Treatment-induced oxidative stress and cellular antioxidant capacity determine response to bortezomib in mantle cell lymphoma.Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs.Efficacy of panobinostat and marizomib in acute myeloid leukemia and bortezomib-resistant models.The 26S proteasome complex: an attractive target for cancer therapy Proteasome inhibitor MG-132 enhances histone deacetylase inhibitor SAHA-induced cell death of chronic myeloid leukemia cells by an ROS-mediated mechanism and downregulation of the Bcr-Abl fusion protein.Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF-κB and Bim Proteasome inhibition and combination therapy for non-Hodgkin's lymphoma: from bench to bedside Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism The peptide derived from the Ig-like domain of human herpesvirus 8 K1 protein induces death in hematological cancer cells.Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia Redox control of leukemia: from molecular mechanisms to therapeutic opportunities.From bortezomib to other inhibitors of the proteasome and beyond.Marizomib activity as a single agent in malignant gliomas: ability to cross the blood-brain barrier.

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P2860

NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells.

http://www.wikidata.org/entity/Q35850681

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2007 nî lūn-bûn

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NPI-0052, a novel proteasome i ...... inhibitors in leukemia cells.

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Claudia P Miller

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David J McConkey

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Joya Chandra

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Kechen Ban

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Mark Munsell

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Melanie E Dujka

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Michael Palladino

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P2860

Structure and functions of the 20S and 26S proteasomes

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

The biochemistry of apoptosis

Proteasome inhibition sensitizes non-small cell lung cancer to histone deacetylase inhibitor-induced apoptosis through the generation of reactive oxygen species.

Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts.

Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors.

Proteasome inhibitors in lung cancer.

Catalytic activities of the 20 S proteasome, a multicatalytic proteinase complex.

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