Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing.
about
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNAMechanisms of resistance to alkylating agentsOverview of base excision repair biochemistryBase excision repair and cancerA model for 3-methyladenine recognition by 3-methyladenine DNA glycosylase I (TAG) from Staphylococcus aureusHypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient miceProliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stageIncision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease VTargeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanineSubstrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survivalSystems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks.Implication of localization of human DNA repair enzyme O6-methylguanine-DNA methyltransferase at active transcription sites in transcription-repair coupling of the mutagenic O6-methylguanine lesion.Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.In vivo repair of methylation damage in Aag 3-methyladenine DNA glycosylase null mouse cellsA novel link to base excision repair?APNG as a prognostic marker in patients with glioblastoma.XRCC1 deficiency influences the cytotoxicity and the genomic instability induced by Me-lex, a specific inducer of N3-methyladenine.Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesisEffect of n3-methyladenine and an isosteric stable analogue on DNA polymerization.ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitorsMethyltransferases mediate cell memory of a genotoxic insultNEIL1 responds and binds to psoralen-induced DNA interstrand crosslinksTranscription and DNA damage: a link to a kink.Germ line variants of human N-methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6-ethenoadenine-induced mutationsAlkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patientsLife without DNA repairFunctional nucleotide excision repair is required for the preferential removal of N-ethylpurines from the transcribed strand of the dihydrofolate reductase gene of Chinese hamster ovary cells.Eukaryotic Y-family polymerases bypass a 3-methyl-2'-deoxyadenosine analog in vitro and methyl methanesulfonate-induced DNA damage in vivoBalancing repair and tolerance of DNA damage caused by alkylating agentsMethylating agents and DNA repair responses: Methylated bases and sources of strand breaks.Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.Evidence for base excision repair processing of DNA interstrand crosslinks.Roles of Aag, Alkbh2, and Alkbh3 in the Repair of Carboxymethylated and Ethylated Thymidine LesionsDrug resistance and DNA repair in leukaemia.High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells.Human methyl purine DNA glycosylase and DNA polymerase beta expression collectively predict sensitivity to temozolomide.Mixed spermatogenic germ cell nuclear extracts exhibit high base excision repair activity.AP endonuclease knockdown enhances methyl methanesulfonate hypersensitivity of DNA polymerase β knockout mouse embryonic fibroblasts.Contribution of base excision repair, nucleotide excision repair, and DNA recombination to alkylation resistance of the fission yeast Schizosaccharomyces pombe.
P2860
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P2860
Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Repair-deficient 3-methyladeni ...... osome damage and cell killing.
@ast
Repair-deficient 3-methyladeni ...... osome damage and cell killing.
@en
type
label
Repair-deficient 3-methyladeni ...... osome damage and cell killing.
@ast
Repair-deficient 3-methyladeni ...... osome damage and cell killing.
@en
prefLabel
Repair-deficient 3-methyladeni ...... osome damage and cell killing.
@ast
Repair-deficient 3-methyladeni ...... osome damage and cell killing.
@en
P2093
P2860
P1433
P1476
Repair-deficient 3-methyladeni ...... osome damage and cell killing.
@en
P2093
B P Engelward
C Kurahara
J Christensen
P2860
P304
P407
P577
1996-02-01T00:00:00Z