AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.
about
Identification of Salvia haenkei as gerosuppressant agent by using an integrated senescence-screening assayEarly-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency.AKT regulates NPM dependent ARF localization and p53mut stability in tumors.Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiencyDifferent mutational characteristics of TSG in cell lines and surgical specimensSenescence and apoptosis: dueling or complementary cell fates?Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescenceEmerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence.Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells.SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradationDichotomy effects of Akt signaling in breast cancer.Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers.Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence.Bisindole-PBD regulates breast cancer cell proliferation via SIRT-p53 axis.Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations.Metabolic regulation by p53 family members.A PTEN inhibitor displays preclinical activity against hepatocarcinoma cellsAntitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism.The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway.MEK1 is required for the development of NRAS-driven leukemia.AKT mediates actinomycin D-induced p53 expression.Autophagy and the Cell Cycle: A Complex Landscape.Synergism between mTOR pathway and ultraviolet radiation in the pathogenesis of squamous cell carcinoma and its implication for solid-organ transplant recipients.Transcriptional regulation of the stress response by mTOR.PI3K/Akt-mediated regulation of p53 in cancer.Antitumor mechanisms when pRb and p53 are genetically inactivated.ASPL-TFE3 Oncoprotein Regulates Cell Cycle Progression and Induces Cellular Senescence by Up-Regulating p21.Single-cell analysis challenges the connection between autophagy and senescence induced by DNA damage.HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer.The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence.p73 regulates serine biosynthesis in cancer.The innate immune factor apolipoprotein L1 restricts HIV-1 infection.Depletion of CSN5 inhibits Ras-mediated tumorigenesis by inducing premature senescence in p53-null cells.Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition.Celecoxib enhances the inhibitory effect of 5-FU on human squamous cell carcinoma proliferation by ROS production.Leptin and Neutrophil-Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus.Activation of Akt characterizes estrogen receptor positive human breast cancers which respond to anthracyclines.Study on Inhibitory Effect of MaiMenDong Decoction and WeiJing Decoction Combination with Cisplatin on NCI-A549 Xenograft in Nude Mice and Its Mechanism.Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stressIdentification of HSP90 inhibitors as a novel class of senolytics.
P2860
Q28818070-80828465-164B-4536-AE2B-51655E6A9D61Q33418786-7F90D3BC-B0AD-467B-AAA2-4CF42531AE87Q34227622-7C3CD05F-A4A1-4818-A20F-6D55A40B7FE9Q34380652-009DF62C-4636-4BE0-84A9-F8D2438B7F38Q34574381-353E08BD-B9F0-4EC8-96DF-E3A3A1AD8BECQ34619554-5FFB3BD8-5093-46F7-8C7F-133FFA3ECD46Q35036570-5041FE19-BAA8-4A2D-A4F5-7B8EA25A73A8Q35174677-BB713C49-C8C1-483B-A655-2AAF14311C85Q36105149-532B4C0E-45F4-424F-BB3B-41F4F872348EQ36379597-A5FCF200-1FDF-45F7-B828-5B2763546627Q36388391-C7EB8D54-94C2-4496-BA21-585A9D16CF41Q36542415-207D6ECD-66D2-4487-AF89-012BEDF7E24FQ36772205-09BA0FD9-D7E1-48F7-B039-3D504DB008E5Q36838991-09F2D013-C204-4ECB-B1EA-1F1E9F12CC1AQ37163727-FADBA5EC-1AB8-4D71-8C4D-8F0D73A2A96CQ37298047-C8159527-ACA8-4757-89B4-E289AEF35A79Q37324522-A519CE35-05F5-47AB-A139-72BBE2CC5487Q37591581-6E92825A-3E53-476F-9C34-5AD719217EB2Q37648588-F99ECE42-6112-4A80-AC6E-96C00EF228BAQ37696978-290B6D6E-8878-43A6-92AF-4F6599F83CEBQ37718441-14CBCCED-2319-4B41-9367-EB34F21FC81AQ37732086-CC0EA170-0C9B-4751-8A89-7836E9CCC084Q38187197-1B65CE22-97C7-4E68-B449-D1EADD2885E8Q38225367-6A796EBC-9B7C-4609-87F5-3C75885A8010Q38238609-77F61E31-1FB0-44FE-BAC0-784AB553C04AQ38285170-BA2075C1-AE76-4105-B829-F651649E678BQ38743525-A48079F2-C0DA-4E9E-A878-13983C69E5B6Q38907601-27E1F277-F379-4385-BB07-62C30A1B6D62Q38945032-A1AA70A2-62F7-4EEE-B347-92F877C89E77Q39018419-5E36E129-88C8-4933-B48C-64788CB1BA59Q39067492-33F141DC-AC40-4835-8876-99930721EA5DQ39068713-26D97577-FFC4-42C8-BBC5-D4CE19BBAAB6Q39249376-FD1BA9DE-2FB1-4616-9981-951BAC0095C5Q39356301-D482423E-1FDA-49E6-BFF6-43CF83FC2598Q40566789-FFDD42AE-98B3-4403-97A4-E1EB5E08020EQ40923689-4D84F728-CFBC-4A57-85B9-DBA72097DB41Q41093512-D321DCFC-6B0D-4DCD-9F38-1DFC292F4563Q41243431-F4E37A37-4EC9-472D-BBE4-F46EFFBFDF4EQ41579911-6CB70670-9F04-4E84-B52C-8DE1E15EA3D8Q41606906-B9DB0D3A-B7D0-4784-9979-9A69F12BB45E
P2860
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
AKT induces senescence in huma ...... geting mTOR during malignancy.
@ast
AKT induces senescence in huma ...... geting mTOR during malignancy.
@en
type
label
AKT induces senescence in huma ...... geting mTOR during malignancy.
@ast
AKT induces senescence in huma ...... geting mTOR during malignancy.
@en
prefLabel
AKT induces senescence in huma ...... geting mTOR during malignancy.
@ast
AKT induces senescence in huma ...... geting mTOR during malignancy.
@en
P2093
P2860
P50
P356
P1433
P1476
AKT induces senescence in huma ...... rgeting mTOR during malignancy
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2011.394
P407
P577
2011-09-12T00:00:00Z