Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy. - Test2 - elhamkhani - TriplyDB

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.

http://www.wikidata.org/entity/Q35909430

about

XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration The unfolded protein response in neurodegenerative diseases: a neuropathological perspective FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy Involvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseases Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1 The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases The burden of trisomy 21 disrupts the proteostasis network in Down syndrome.Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease.Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis.Lack of XBP-1 impedes murine cytomegalovirus gene expression.A common gene expression signature in Huntington's disease patient brain regions.ER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtin UPR, autophagy, and mitochondria crosstalk underlies the ER stress response Getting the better of ER stress.Chaperone-mediated autophagy in the kidney: the road more traveled Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease.Interplay between unfolded protein response and autophagy promotes tumor drug resistance Mutant uromodulin expression leads to altered homeostasis of the endoplasmic reticulum and activates the unfolded protein response.Oxidant stress and signal transduction in the nervous system with the PI 3-K, Akt, and mTOR cascade Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse.XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells ER stress: Autophagy induction, inhibition and selection.Potential for therapeutic manipulation of the UPR in disease.Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders.Forkhead transcription factors: new considerations for alzheimer's disease and dementia.The ire-1 ER stress-response pathway is required for normal secretory-protein metabolism in C. elegans.Protein aggregation activates erratic stress response in dietary restricted yeast cells.MIST1 Links Secretion and Stress as Both Target and Regulator of the UPR.Network analysis of human post-mortem microarrays reveals novel genes, microRNAs, and mechanistic scenarios of potential importance in fighting huntington's disease.Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice.A brief history of triplet repeat diseases.

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Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.

http://www.wikidata.org/entity/Q35909430

description

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Targeting the UPR transcriptio ...... lation of FoxO1 and autophagy.

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Targeting the UPR transcriptio ...... lation of FoxO1 and autophagy.

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Targeting the UPR transcriptio ...... lation of FoxO1 and autophagy.

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Targeting the UPR transcriptio ...... lation of FoxO1 and autophagy.

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Targeting the UPR transcriptio ...... lation of FoxO1 and autophagy.

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Targeting the UPR transcriptio ...... lation of FoxO1 and autophagy.

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Targeting the UPR transcriptio ...... lation of FoxO1 and autophagy.

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Alicia Figueroa

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Benjamin Caballero

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Claudia Molina

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Claudio Hetz

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Craig Wirth

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Felipe A Court

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P2860

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Plasma cell differentiation requires the transcription factor XBP-1

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

The unfolded protein response: integrating stress signals through the stress sensor IRE1α

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

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2245-2262

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10.1093/HMG/DDS040

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10

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21

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Ana María Cuervo

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2012-02-14T00:00:00Z

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221835692

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22337954

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Huntington disease

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3335312

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