Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt - Test2 - elhamkhani - TriplyDB

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

http://www.wikidata.org/entity/Q35929017

about

Inflammasome components ASC and AIM2 modulate the acute phase of biomaterial implant-induced foreign body responses NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota.Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity Chemopreventive activity of GEN-27, a genistein derivative, in colitis-associated cancer is mediated by p65-CDX2-β-catenin axis.NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-κB signaling.Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway.NLRC4 suppresses melanoma tumor progression independently of inflammasome activation.The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.Inflammasomes in Myeloid Cells: Warriors Within.Inflammasomes in Inflammation-Induced Cancer.The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease Genomic and transcriptomic heterogeneity of colorectal tumors arising in Lynch Syndrome.NLR-regulated pathways in cancer: opportunities and obstacles for therapeutic interventions.HBx-mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis.Mitochondrial DNA sensing by STING signaling participates in inflammation, cancer and beyond.Inflammasome Complexes: Emerging Mechanisms and Effector Functions.The contribution of inflammasome components on macrophage response to surface nanotopography and chemistry.Absent in melanoma 2 proteins in the development of cancer.Microbiota as a mediator of cancer progression and therapy.AIM2 regulates viability and apoptosis in human colorectal cancer cells via the PI3K/Akt pathway.Alternative functions for the multifarious inflammasome.Inflammasomes and Cancer.Nucleic acid sensing pattern recognition receptors in the development of colorectal cancer and colitis.Inflammasomes and intestinal inflammation.Redox-dependent regulation of hepatocyte absent in melanoma 2 inflammasome activation in sterile liver injury in mice.Mechanisms governing inflammasome activation, assembly and pyroptosis induction.Mechanisms regulating immune surveillance of cellular stress in cancer.AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection.Maturation-dependent expression of AIM2 in human B-cells.Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation.The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.Inflammasomes and Cancer: The Dynamic Role of the Inflammasome in Tumor Development Innate sensing of cancer's non-immunologic hallmarks.The AIM2 inflammasome: Sensor of pathogens and cellular perturbations.The emerging role of ASC in dendritic cell metabolism during Chlamydia infection.Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.Inflammasome activation and assembly at a glance.

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Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

http://www.wikidata.org/entity/Q35929017

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2015年論文

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2015年论文

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2015年论文

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Inflammasome-independent role ...... morigenesis via DNA-PK and Akt

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Inflammasome-independent role ...... morigenesis via DNA-PK and Akt

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Inflammasome-independent role ...... morigenesis via DNA-PK and Akt

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Inflammasome-independent role ...... morigenesis via DNA-PK and Akt

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Inflammasome-independent role ...... morigenesis via DNA-PK and Akt

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Inflammasome-independent role ...... morigenesis via DNA-PK and Akt

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Nature Medicine

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Inflammasome-independent role ...... morigenesis via DNA-PK and Akt

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A Alicia Koblansky

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Agnieszka D Truax

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Alex S Petrucelli

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Arlin B Rogers

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Beckley K Davis

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Christian Jobin

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Jenny P Y Ting

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Justin E Wilson

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Marcus Mühlbauer

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Monika Schneider

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model

Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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10.1038/NM.3908

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8

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21

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Brianne R Barker

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2015-06-24T00:00:00Z

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1023962393

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26107252

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4529369

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