H bonding at the helix-bundle crossing controls gating in Kir potassium channels. - Test2 - elhamkhani - TriplyDB

H bonding at the helix-bundle crossing controls gating in Kir potassium channels.

H bonding at the helix-bundle crossing controls gating in Kir potassium channels.

http://www.wikidata.org/entity/Q35944687

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Structural changes in the cytoplasmic pore of the Kir1.1 channel during pHi-gating probed by FRET How highly charged anionic lipids bind and regulate ion channels Control of KirBac3.1 Potassium Channel Gating at the Interface between Cytoplasmic Domains Separate gating mechanisms mediate the regulation of K2P potassium channel TASK-2 by intra- and extracellular pH Structural correlates of selectivity and inactivation in potassium channels.Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities.State-dependent network connectivity determines gating in a K+ channel Phosphatidylinositol 4,5-bisphosphate activates Slo3 currents and its hydrolysis underlies the epidermal growth factor-induced current inhibition Molecular mechanisms of EAST/SeSAME syndrome mutations in Kir4.1 (KCNJ10)Molecular basis of decreased Kir4.1 function in SeSAME/EAST syndrome.Modulation of Kir1.1 inactivation by extracellular Ca and Mg.A Kir6.2 pore mutation causes inactivation of ATP-sensitive potassium channels by disrupting PIP2-dependent gating.Molecular mechanism of pH sensing in KcsA potassium channels.Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels.Residues at the outer mouth of Kir1.1 determine K-dependent gating.Direct injection of cell-free Kir1.1 protein into Xenopus oocytes replicates single-channel currents derived from Kir1.1 mRNA.Allosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel.A carboxy-terminal inter-helix linker as the site of phosphatidylinositol 4,5-bisphosphate action on Kv7 (M-type) K+ channels.Long-pore electrostatics in inward-rectifier potassium channels.An intersubunit salt bridge near the selectivity filter stabilizes the active state of Kir1.1.Structural Basis for Differences in Dynamics Induced by Leu Versus Ile Residues in the CD Loop of Kir Channels Secondary anionic phospholipid binding site and gating mechanism in Kir2.1 inward rectifier channels.A comprehensive guide to the ROMK potassium channel: form and function in health and disease.The salt-wasting phenotype of EAST syndrome, a disease with multifaceted symptoms linked to the KCNJ10 K+ channel.Regulation of ion channels by membrane lipids.The pore structure and gating mechanism of K2P channels.Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome.Kir4.1 K+ channels are regulated by external cations.Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels.Genetic selection of activatory mutations in KcsA.Insights into the structural nature of the transition state in the Kir channel gating pathway.Ion channel regulation by phosphoinositides analyzed with VSPs-PI(4,5)P2 affinity, phosphoinositide selectivity, and PI(4,5)P2 pool accessibility.Characterization of a binding site for anionic phospholipids on KCNQ1.The endosomal trafficking factors CORVET and ESCRT suppress plasma membrane residence of the renal outer medullary potassium channel (ROMK).Druggability of the inward rectifier family: a hope for rare channelopathies?Protein kinase C mediated pH(i)-regulation of ROMK1 channels via a phosphatidylinositol-4,5-bisphosphate-dependent mechanism.Potassium-dependent activation of Kir4.2 K⁺ channels.

P2860

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P2860

H bonding at the helix-bundle crossing controls gating in Kir potassium channels.

http://www.wikidata.org/entity/Q35944687

description

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name

H bonding at the helix-bundle crossing controls gating in Kir potassium channels.

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H bonding at the helix-bundle crossing controls gating in Kir potassium channels.

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H bonding at the helix-bundle crossing controls gating in Kir potassium channels.

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H bonding at the helix-bundle crossing controls gating in Kir potassium channels.

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prefLabel

H bonding at the helix-bundle crossing controls gating in Kir potassium channels.

@ast

H bonding at the helix-bundle crossing controls gating in Kir potassium channels.

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H bonding at the helix-bundle crossing controls gating in Kir potassium channels.

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Lijun Shang

http://www.w3.org/2001/XMLSchema#string

Mark S P Sansom

http://www.w3.org/2001/XMLSchema#string

Markus Rapedius

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Philip W Fowler

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Stephen J Tucker

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Thomas Baukrowitz

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P2860

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

The inward rectification mechanism of the HERG cardiac potassium channel

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

All-atom empirical potential for molecular modeling and dynamics studies of proteins

VMD: visual molecular dynamics

Scalable molecular dynamics with NAMD

A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channels

K(+)-dependent gating of K(ir)1.1 channels is linked to pH gating through a conformational change in the pore

Lack of the Kir4.1 channel subunit abolishes K+ buffering properties of astrocytes in the ventral respiratory group: impact on extracellular K+ regulation

Molecular determinants of gating at the potassium-channel selectivity filter.

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