The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression
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The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expressionTALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cellsProteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2-related factors 1 and 2 (NRF1 and NRF2).Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasome inhibitionO-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1A regulation loop between Nrf1α and MRTF-A controls migration and invasion in MDA-MB-231 breast cancer cellsNach Is a Novel Subgroup at an Early Evolutionary Stage of the CNC-bZIP Subfamily Transcription Factors from the Marine Bacteria to HumansNrf1D Is the First Candidate Secretory Transcription Factor in the Blood Plasma, Its Precursor Existing as a Unique Redox-Sensitive Transmembrane CNC-bZIP Protein in Hemopoietic and Somatic Tissues
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The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression
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2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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name
The selective post-translation ...... ially regulate gene expression
@ast
The selective post-translation ...... ially regulate gene expression
@en
type
label
The selective post-translation ...... ially regulate gene expression
@ast
The selective post-translation ...... ially regulate gene expression
@en
prefLabel
The selective post-translation ...... ially regulate gene expression
@ast
The selective post-translation ...... ially regulate gene expression
@en
P2093
P2860
P356
P1433
P1476
The selective post-translation ...... ially regulate gene expression
@en
P2093
Huakan Zhao
Shaojun Li
Yuancai Xiang
P2860
P2888
P356
10.1038/SREP12983
P407
P577
2015-08-13T00:00:00Z