Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice.
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Nrf1 in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF alpha promoter in stimulated mast cellsMolecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3Chemoprotection by phenolic antioxidantsMolecular basis of electrophilic and oxidative defense: promises and perils of Nrf2Role of Nrf1 in antioxidant response element-mediated gene expression and beyondRole of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanismConcerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damagemTORC1 signaling activates NRF1 to increase cellular proteasome levelsThe conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegansRegulation of Drosophila metamorphosis by xenobiotic response regulatorsThe C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expressionThe CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblastsTranscription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoformNrf1 is critical for redox balance and survival of liver cells during developmentTwo domains of the human bZIP transcription factor TCF11 are necessary for transactivationThe p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcriptionLoss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegenerationLiver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasiaNrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting functionTranscription factor NF-E2-related factor 1 impairs glucose metabolism in miceDual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanismsNegative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulumCNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretionEmbryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteinsInduction of Herpud1 expression by ER stress is regulated by Nrf1The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxiaThe CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiationMechanistic studies of the Nrf2-Keap1 signaling pathwayTranscription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cellsGlycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in miceLong isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytesThe casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expressionNrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genesNrf2 is essential for protection against acute pulmonary injury in miceStress-activated cap'n'collar transcription factors in aging and human diseaseGenetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survivalRegulation of Nrf2-an updateRegulation of APC development, immune response, and autoimmunity by Bach1/HO-1 pathway in miceA small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy
P2860
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P2860
Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice.
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Targeted disruption of the ubi ...... nd embryonic lethality in mice
@nl
Targeted disruption of the ubi ...... d embryonic lethality in mice.
@ast
Targeted disruption of the ubi ...... d embryonic lethality in mice.
@en
Targeted disruption of the ubi ...... d embryonic lethality in mice.
@en-gb
type
label
Targeted disruption of the ubi ...... nd embryonic lethality in mice
@nl
Targeted disruption of the ubi ...... d embryonic lethality in mice.
@ast
Targeted disruption of the ubi ...... d embryonic lethality in mice.
@en
Targeted disruption of the ubi ...... d embryonic lethality in mice.
@en-gb
prefLabel
Targeted disruption of the ubi ...... nd embryonic lethality in mice
@nl
Targeted disruption of the ubi ...... d embryonic lethality in mice.
@ast
Targeted disruption of the ubi ...... d embryonic lethality in mice.
@en
Targeted disruption of the ubi ...... d embryonic lethality in mice.
@en-gb
P2093
P2860
P921
P3181
P356
P1433
P1476
Targeted disruption of the ubi ...... d embryonic lethality in mice.
@en
P2093
P2860
P304
P3181
P356
10.1093/EMBOJ/17.6.1779
P407
P577
1998-03-01T00:00:00Z