Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
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The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complexCoronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein TobThe Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferationInteraction of antiproliferative protein Tob with the CCR4-NOT deadenylase complexStructural basis for the antiproliferative activity of the Tob-hCaf1 complexTransducer of ERBB2.1 (TOB1) as a Tumor Suppressor: A Mechanistic PerspectiveHDACi Valproic Acid (VPA) and Suberoylanilide Hydroxamic Acid (SAHA) Delay but Fail to Protect against Warm Hepatic Ischemia-Reperfusion InjuryThe BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs.Early origins of heart disease: low birth weight and determinants of cardiomyocyte endowmentB-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signalingRegulators of cellular levels of histone acetylation in Saccharomyces cerevisiaeSuppression of human lung cancer cell proliferation and metastasis in vitro by the transducer of ErbB-2.1 (TOB1).Tob1 is a constitutively expressed repressor of liver regenerationEpigenetic silencing of a proapoptotic cell adhesion molecule, the immunoglobulin superfamily member IGSF4, by promoter CpG methylation protects Hodgkin lymphoma cells from apoptosisHDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression.Molecular characterization of Tob1 in muscle development in pigsAcquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation.Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities.Gene Expression Profiling in Hereditary, BRCA1-linked Breast Cancer: Preliminary ReportTurning down the system: counter-regulatory mechanisms in bone and adaptive immunity.Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT.The role of the TOB1 gene in growth suppression of hepatocellular carcinoma.Apoptosis during embryonic tissue remodeling is accompanied by cell senescence.Genomic Analyses of Sperm Fate Regulator Targets Reveal a Common Set of Oogenic mRNAs in Caenorhabditis elegansxBtg-x regulates Wnt/beta-Catenin signaling during early Xenopus development.ERK MAP kinase in G cell cycle progression and cancer.Crystallization and preliminary crystallographic analysis of the Tob-hCaf1 complex.Tob1 induces apoptosis and inhibits proliferation, migration and invasion of gastric cancer cells by activating Smad4 and inhibiting β‑catenin signalingTob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity.Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signalingThe dark side of a tumor suppressor: anti-apoptotic p53.Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitisIdentification of novel subregions of LOH in gastric cancer and analysis of the HIC1 and TOB1 tumor suppressor genes in these subregions.Tob, a member of the APRO family, regulates immunological quiescence and tumor suppression.BTG/TOB factors impact deadenylases.Flipping the switch from g1 to s phase with e3 ubiquitin ligasesC. elegans FOG-3/Tob can either promote or inhibit germline proliferation, depending on gene dosage and genetic context.Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob.Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation.TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop.
P2860
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P2860
Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
@ast
Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
@en
type
label
Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
@ast
Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
@en
prefLabel
Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
@ast
Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
@en
P2093
P2860
P356
P1433
P1476
Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
@en
P2093
Eri H Yoshida
Hitoshi Satoh
Junko K Tsuzuku
Kenzaburo Tani
Masami Suganuma
Masato Komoda
Reiko K Kunisaki
Shigeo Mori
Tadashi Yamamoto
Takahisa Nakamura
P2860
P304
P356
10.1101/GAD.1088003
P577
2003-05-01T00:00:00Z