Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases.
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Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerizationA Hot Oxidant, 3-NO 2 Y 122 Radical, Unmasks Conformational Gating in Ribonucleotide ReductaseEvaluating the Therapeutic Potential of a Non-Natural Nucleotide That Inhibits Human Ribonucleotide ReductaseStructural interconversions modulate activity of Escherichia coli ribonucleotide reductaseRole of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide ReductaseTangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductaseInhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme.Algorithmic modeling quantifies the complementary contribution of metabolic inhibitions to gemcitabine efficacyMolecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductaseThe conserved Lys-95 charged residue cluster is critical for the homodimerization and enzyme activity of human ribonucleotide reductase small subunit M2Equilibrium model selection: dTTP induced R1 dimerizationDif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunitAutomated mass action model space generation and analysis methods for two-reactant combinatorially complex equilibriums: an analysis of ATP-induced ribonucleotide reductase R1 hexamerization data.Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA ReplicationConserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesisRibonucleotide reductase metallocofactor: assembly, maintenance and inhibition.The structural basis for the allosteric regulation of ribonucleotide reductase.Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: covalent modificationMechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5'-diphosphateTwo distinct mechanisms of inactivation of the class Ic ribonucleotide reductase from Chlamydia trachomatis by hydroxyurea: implications for the protein gating of intersubunit electron transfer.On model ensemble analyses of nonmonotonic data.Molecular Strategies of Deoxynucleotide Triphosphate Supply Inhibition Used in the Treatment of Gynecologic MalignanciesClofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunitModulation of the ribonucleotide reductase M1-gemcitabine interaction in vivo by N-ethylmaleimide.Characterization and drug sensitivity profiling of primary malignant mesothelioma cells from pleural effusions.DNA repair mechanisms in cancer development and therapyClofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamersTherapeutic Mechanisms of Treatment in Cervical and Vaginal Cancer.Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species.Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy.Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer.Identification of Non-nucleoside Human Ribonucleotide Reductase ModulatorsDiscovery of posttranslational maturation by self-subunit swapping.The prototypic class Ia ribonucleotide reductase from Escherichia coli: still surprising after all these years.Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.5-aza-2',2'-Difluroro Deoxycytidine (NUC013): A Novel Nucleoside DNA Methyl Transferase Inhibitor and Ribonucleotide Reductase Inhibitor for the Treatment of CancersiRNA knockdown of mitochondrial thymidine kinase 2 (TK2) sensitizes human tumor cells to gemcitabinePredictors of chemotherapy efficacy in non-small-cell lung cancer: a challenging landscape.Equilibration of tyrosyl radicals (Y356•, Y731•, Y730•) in the radical propagation pathway of the Escherichia coli class Ia ribonucleotide reductase.Use of 2,3,5-F(3)Y-β2 and 3-NH(2)Y-α2 to study proton-coupled electron transfer in Escherichia coli ribonucleotide reductase.
P2860
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P2860
Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Enhanced subunit interactions ...... bit ribonucleotide reductases.
@ast
Enhanced subunit interactions ...... bit ribonucleotide reductases.
@en
type
label
Enhanced subunit interactions ...... bit ribonucleotide reductases.
@ast
Enhanced subunit interactions ...... bit ribonucleotide reductases.
@en
prefLabel
Enhanced subunit interactions ...... bit ribonucleotide reductases.
@ast
Enhanced subunit interactions ...... bit ribonucleotide reductases.
@en
P2860
P356
P1476
Enhanced subunit interactions ...... ibit ribonucleotide reductases
@en
P2093
JoAnne Stubbe
P2860
P304
14324-14329
P356
10.1073/PNAS.0706803104
P407
P577
2007-08-28T00:00:00Z