Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit
about
Antimutator variants of DNA polymerasesYeast Dun1 Kinase Regulates Ribonucleotide Reductase Small Subunit Localization in Response to Iron Deficiency.Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit.The late-annotated small ORF LSO1 is a target gene of the iron regulon of Saccharomyces cerevisiae.Genetic instability in budding and fission yeast-sources and mechanismsIxr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP poolsThe conserved Lys-95 charged residue cluster is critical for the homodimerization and enzyme activity of human ribonucleotide reductase small subunit M2Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesisRibonucleotide reductase metallocofactor: assembly, maintenance and inhibition.Yeast Dun1 kinase regulates ribonucleotide reductase inhibitor Sml1 in response to iron deficiencyNormal telomere length maintenance in Saccharomyces cerevisiae requires nuclear import of the ever shorter telomeres 1 (Est1) protein via the importin alpha pathway.The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damageMechanisms of mutagenesis in vivo due to imbalanced dNTP pools.Ribosome synthesis-unrelated functions of the preribosomal factor Rrp12 in cell cycle progression and the DNA damage response.Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelitydNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Regulation of ribonucleotide reductase in response to iron deficiency.Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotypeMutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint.Telomere length homeostasis responds to changes in intracellular dNTP pools.Cytoplasmic localization of Hug1p, a negative regulator of the MEC1 pathway, coincides with the compartmentalization of Rnr2p-Rnr4p.Mec1/ATR, the Program Manager of Nucleic Acids Inc.The Intra-S Checkpoint Responses to DNA Damage.Surviving chromosome replication: the many roles of the S-phase checkpoint pathway.DNA damage response: three levels of DNA repair regulation.Targeting ribonucleotide reductase for cancer therapy.The available SRL3 deletion strain of Saccharomyces cerevisiae contains a truncation of DNA damage tolerance protein Mms2: Implications for Srl3 and Mms2 functions.Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis.Functional Analysis of Ribonucleotide Reductase from Cordyceps militaris Expressed in Escherichia coli.Regulation of ribonucleotide reductase during iron limitation.Regulation of ribonucleotide reductase by Spd1 involves multiple mechanisms.A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1.Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres.Checkpoint-dependent RNR induction promotes fork restart after replicative stress.Unique molecular mechanisms for maintenance and alteration of genetic information in the budding yeast Saccharomyces cerevisiae.Clb6-Cdc28 Promotes Ribonucleotide Reductase Subcellular Redistribution during S Phase.
P2860
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P2860
Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Dif1 controls subcellular loca ...... clear import of the R2 subunit
@ast
Dif1 controls subcellular loca ...... clear import of the R2 subunit
@en
type
label
Dif1 controls subcellular loca ...... clear import of the R2 subunit
@ast
Dif1 controls subcellular loca ...... clear import of the R2 subunit
@en
prefLabel
Dif1 controls subcellular loca ...... clear import of the R2 subunit
@ast
Dif1 controls subcellular loca ...... clear import of the R2 subunit
@en
P2860
P356
P1476
Dif1 controls subcellular loca ...... clear import of the R2 subunit
@en
P2093
Mingxia Huang
Xiaorong Wu
P2860
P304
P356
10.1128/MCB.01388-08
P407
P577
2008-10-06T00:00:00Z