Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults.
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Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approachHb E/beta-thalassaemia: a common & clinically diverse disorderGenome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemiaCurrent and future alternative therapies for beta-thalassemia majorGenomic approaches to identifying targets for treating β hemoglobinopathiesEpigenetic regulation of fetal globin gene expression in adult erythroid cellsSequence variants affecting eosinophil numbers associate with asthma and myocardial infarctionGlobal genetic architecture of an erythroid quantitative trait locus, HMIP-2Experimental generation of SNP haplotype signatures in patients with sickle cell anaemiaHemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients.Generation of a genomic reporter assay system for analysis of γ- and β-globin gene regulation.Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype.How I use hydroxyurea to treat young patients with sickle cell anemia.Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLAAmelioration of Sardinian beta0 thalassemia by genetic modifiers.Fetal globin expression is regulated by Friend of Prmt1.LIN28A expression reduces sickling of cultured human erythrocytes.Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia.Genetic modifiers of HbF and response to hydroxyurea in sickle cell disease.Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotypeMicroRNA-486-3p regulates γ-globin expression in human erythroid cells by directly modulating BCL11A.Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.Update on fetal hemoglobin gene regulation in hemoglobinopathiesThe genetics of hemoglobin A2 regulation in sickle cell anemiaA 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expressionGenotyping of BCL11A and HBS1L-MYB SNPs associated with fetal haemoglobin levels: a SNaPshot minisequencing approachFetal hemoglobin in sickle cell anemiaAssociation of variants at BCL11A and HBS1L-MYB with hemoglobin F and hospitalization rates among sickle cell patients in Cameroon.Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms.Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia.Variants in genetic modifiers of β-thalassemia can help to predict the major or intermedia type of the diseaseGenetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancerHaemoglobinopathies in southeast Asia.Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid developmentTen novel mutations in the erythroid transcription factor KLF1 gene associated with increased fetal hemoglobin levels in adults.Fetal hemoglobin in sickle cell anemia: molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans.Mapping complex disease traits with global gene expression.Genetic modifiers of sickle cell disease
P2860
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P2860
Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Intergenic variants of HBS1L-M ...... l hemoglobin levels in adults.
@ast
Intergenic variants of HBS1L-M ...... l hemoglobin levels in adults.
@en
type
label
Intergenic variants of HBS1L-M ...... l hemoglobin levels in adults.
@ast
Intergenic variants of HBS1L-M ...... l hemoglobin levels in adults.
@en
prefLabel
Intergenic variants of HBS1L-M ...... l hemoglobin levels in adults.
@ast
Intergenic variants of HBS1L-M ...... l hemoglobin levels in adults.
@en
P2093
P2860
P50
P356
P1476
Intergenic variants of HBS1L-M ...... l hemoglobin levels in adults.
@en
P2093
Ageliki Gerovasilli
Chad Garner
Fumihiko Matsuda
James Close
Karin Wahlberg
Martin Farrall
Masao Yamaguchi
Nicholas Silver
P2860
P304
11346-11351
P356
10.1073/PNAS.0611393104
P407
P577
2007-06-25T00:00:00Z