SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB.
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Expanding the substantial interactome of NEMO using protein microarraysCullin family proteins and tumorigenesis: genetic association and molecular mechanismsGenetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligasesDEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagyInactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesisEndothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis.Signal transduction molecules as targets for cancer prevention.Inactivation of SAG E3 ubiquitin ligase blocks embryonic stem cell differentiation and sensitizes leukemia cells to retinoid acid.Small RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer TargetsInactivation of Sag/Rbx2/Roc2 e3 ubiquitin ligase triggers senescence and inhibits kras-induced immortalizationPrognostic role of sensitive-to-apoptosis gene expression in rectal cancerSAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradationErbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesisSCF E3 ubiquitin ligases as anticancer targets.COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis.Molecular mechanisms and clinical implications of reversible protein S-glutathionylation.Role of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer.Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis.RNF7 knockdown inhibits prostate cancer tumorigenesis by inactivation of ERK1/2 pathway.Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase.Cullin-RING Ligases as attractive anti-cancer targets.Role of E3 ubiquitin ligases in lung cancer.Ubiquitination involved enzymes and cancer.Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells.Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing targetSAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization.Ubiquitin-Specific Protease USP6 Regulates the Stability of the c-Jun Protein.Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy.
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P2860
SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
SAG/ROC2 E3 ligase regulates s ...... 1 and IkappaB-alpha/NF-kappaB.
@ast
SAG/ROC2 E3 ligase regulates s ...... 1 and IkappaB-alpha/NF-kappaB.
@en
type
label
SAG/ROC2 E3 ligase regulates s ...... 1 and IkappaB-alpha/NF-kappaB.
@ast
SAG/ROC2 E3 ligase regulates s ...... 1 and IkappaB-alpha/NF-kappaB.
@en
prefLabel
SAG/ROC2 E3 ligase regulates s ...... 1 and IkappaB-alpha/NF-kappaB.
@ast
SAG/ROC2 E3 ligase regulates s ...... 1 and IkappaB-alpha/NF-kappaB.
@en
P2093
P2860
P356
P1476
SAG/ROC2 E3 ligase regulates s ...... P1 and IkappaB-alpha/NF-kappaB
@en
P2093
P2860
P304
P356
10.1083/JCB.200612067
P407
P577
2007-09-01T00:00:00Z