Structural basis for assembly and disassembly of the CRM1 nuclear export complex
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An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1Structural basis for the nuclear export activity of Importin13Structural basis for leucine-rich nuclear export signal recognition by CRM1A structurally plastic ribonucleoprotein complex mediates post-transcriptional gene regulation in HIV-1Capturing Biological Activity in Natural Product Fragments by Chemical SynthesisNuclear export of proteins and drug resistance in cancerReversible Oxidation of a Conserved Methionine in the Nuclear Export Sequence Determines Subcellular Distribution and Activity of the Fungal Nitrate Regulator NirAStructures of the tRNA export factor in the nuclear and cytosolic statesAntileukemic activity of nuclear export inhibitors that spare normal hematopoietic cellsStructural basis for cooperativity of CRM1 export complex formationNuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1Atomic basis of CRM1-cargo recognition, release and inhibitionRecognition of nuclear targeting signals by Karyopherin-β proteins.Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agentsNESmapper: accurate prediction of leucine-rich nuclear export signals using activity-based profiles.Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1.Formation of a Trimeric Xpo1-Ran[GTP]-Ded1 Exportin Complex Modulates ATPase and Helicase Activities of Ded1Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein.NESdb: a database of NES-containing CRM1 cargoesSequence and structural analyses of nuclear export signals in the NESdb databaseRole of immediate early protein ICP27 in the differential sensitivity of herpes simplex viruses 1 and 2 to leptomycin BElectrostatic interactions involving the extreme C terminus of nuclear export factor CRM1 modulate its affinity for cargo.Mechanistic insights from the recent structures of the CRM1 nuclear export complex and its disassembly intermediateThe myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway.CRM1 is a cellular target of curcumin: new insights for the myriad of biological effects of an ancient spice.XPO1 in B cell hematological malignancies: from recurrent somatic mutations to targeted therapy.A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K.A non-canonical mechanism for Crm1-export cargo complex assembly.KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells.Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice.The dependence of Ig class-switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin.Verdinexor Targeting of CRM1 is a Promising Therapeutic Approach against RSV and Influenza Viruses.The Rules and Functions of Nucleocytoplasmic Shuttling Proteins.
P2860
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P2860
Structural basis for assembly and disassembly of the CRM1 nuclear export complex
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Structural basis for assembly and disassembly of the CRM1 nuclear export complex
@ast
Structural basis for assembly and disassembly of the CRM1 nuclear export complex
@en
type
label
Structural basis for assembly and disassembly of the CRM1 nuclear export complex
@ast
Structural basis for assembly and disassembly of the CRM1 nuclear export complex
@en
prefLabel
Structural basis for assembly and disassembly of the CRM1 nuclear export complex
@ast
Structural basis for assembly and disassembly of the CRM1 nuclear export complex
@en
P2093
P2860
P356
P1476
Structural basis for assembly and disassembly of the CRM1 nuclear export complex
@en
P2093
Anindita Biswas
Xiuhua Dong
Yuh Min Chook
P2860
P2888
P304
P356
10.1038/NSMB.1586
P577
2009-04-01T00:00:00Z