IL-7 promotes T cell proliferation through destabilization of p27Kip1. - Test2 - elhamkhani - TriplyDB

IL-7 promotes T cell proliferation through destabilization of p27Kip1.

IL-7 promotes T cell proliferation through destabilization of p27Kip1.

http://www.wikidata.org/entity/Q36228431

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Protein kinase C signaling and cell cycle regulation Targeting Homeostatic T Cell Proliferation to Control Beta-Cell Autoimmunity Visualization and identification of IL-7 producing cells in reporter mice Genome-wide functional analysis of human cell-cycle regulators.Absence of both IL-7 and IL-15 severely impairs the development of CD8 T cell response against Toxoplasma gondii.Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.Interleukin-7 mediates glucose utilization in lymphocytes through transcriptional regulation of the hexokinase II gene The interaction of LCK and the CD4 co-receptor alters the dose response of T-cells to interleukin-7.Adaptive immunity to murine skin commensals.IL-7Rα deficiency in p53null mice exacerbates thymocyte telomere erosion and lymphomagenesis TSC1/2 signaling complex is essential for peripheral naïve CD8+ T cell survival and homeostasis in mice.JunD/AP-1-mediated gene expression promotes lymphocyte growth dependent on interleukin-7 signal transduction.Interleukin-7 influences FOXP3+CD4+ regulatory T cells peripheral homeostasis.Cdc25A-driven proliferation regulates CD62L levels and lymphocyte movement in response to interleukin-7.Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity Interferon-α inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling.The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis.Decreased interleukin 7 responsiveness of T lymphocytes in patients with idiopathic CD4 lymphopenia The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes.Effects of IL-7 on memory CD8 T cell homeostasis are influenced by the timing of therapy in mice Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations.T-cell intrinsic and extrinsic mechanisms of p27Kip1 in the regulation of CD8 T-cell memory.Telomerase is involved in IL-7-mediated differential survival of naive and memory CD4+ T cells.Sequential administration of cytokine genes to enhance cellular immune responses and CD4 (+) T memory cells during DNA vaccination.Pituitary adenylate cyclase-activating peptide and vasoactive intestinal polypeptide bias Langerhans cell Ag presentation toward Th17 cells.Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1.Interlinking interleukin-7.Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance.Regulation of T cell-dendritic cell interactions by IL-7 governs T-cell activation and homeostasis.Regulation of B-cell entry into the cell cycle Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1.Tumor immune therapy: lessons from infection and implications for cancer - can IL-7 help overcome immune inhibitory networks?Interleukin-7 Modulates Anti-Tumor CD8+ T Cell Responses via Its Action on Host Cells.Memory CD4 T cells induce selective expression of IL-27 in CD8+ dendritic cells and regulate homeostatic naive T cell proliferation.Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway.Chimeric switch receptor: switching for improved adoptive T-cell therapy against cancers.Spontaneous T Cell Proliferation: A Physiologic Process to Create and Maintain Homeostatic Balance and Diversity of the Immune System.

P2860

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P2860

IL-7 promotes T cell proliferation through destabilization of p27Kip1.

http://www.wikidata.org/entity/Q36228431

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

IL-7 promotes T cell proliferation through destabilization of p27Kip1.

@ast

IL-7 promotes T cell proliferation through destabilization of p27Kip1.

@en

type

label

IL-7 promotes T cell proliferation through destabilization of p27Kip1.

@ast

IL-7 promotes T cell proliferation through destabilization of p27Kip1.

@en

prefLabel

IL-7 promotes T cell proliferation through destabilization of p27Kip1.

@ast

IL-7 promotes T cell proliferation through destabilization of p27Kip1.

@en

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Journal of Experimental Medicine

P1476

IL-7 promotes T cell proliferation through destabilization of p27Kip1.

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P2093

Annette R Khaled

http://www.w3.org/2001/XMLSchema#string

Eiman Aleem

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Philipp Kaldis

http://www.w3.org/2001/XMLSchema#string

Qiong Jiang

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Scott K Durum

http://www.w3.org/2001/XMLSchema#string

Wen Qing Li

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P2860

CDK inhibitors: positive and negative regulators of G1-phase progression

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice

The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression

Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

Cyclin-dependent kinases: engines, clocks, and microprocessors

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7284075

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16492801

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2118250

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