Selective killing of p53-deficient cancer cells by SP600125. - Test2 - elhamkhani - TriplyDB

Selective killing of p53-deficient cancer cells by SP600125.

Selective killing of p53-deficient cancer cells by SP600125.

http://www.wikidata.org/entity/Q36238666

about

PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility Transgenerational cell fate profiling: a method for the graphical presentation of complex cell cycle alterations Characterization of novel MPS1 inhibitors with preclinical anticancer activity JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis.A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.Harnessing the p53-PUMA axis to overcome DNA damage resistance in renal cell carcinoma DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphoma Immunosurveillance against tetraploidization-induced colon tumorigenesis.Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition.Analgesic, anti-inflammatory and anticancer activities of extra virgin olive oil.Purified Lesser weever fish venom (Trachinus vipera) induces eryptosis, apoptosis and cell cycle arrest.Multicellular spheroids from normal and neoplastic thyroid tissues as a suitable model to test the effects of multikinase inhibitors.Heterogeneity in sarcoma cell lines reveals enhanced motility of tetraploid versus diploid cells.SP600125 has a remarkable anticancer potential against undifferentiated thyroid cancer through selective action on ROCK and p53 pathways.Functional and Structural Characterization of Bub3·BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells.TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability.TP53 mutation-correlated genes predict the risk of tumor relapse and identify MPS1 as a potential therapeutic kinase in TP53-mutated breast cancers.Azacytidine and erlotinib exert synergistic effects against acute myeloid leukemia.Mitotic Kinases and p53 Signaling.JNK, p38, ERK, and SGK1 Inhibitors in Cancer.Role of C-Jun N-terminal Kinase in Hepatocellular Carcinoma Development.Preferential killing of p53-deficient cancer cells by reversine.Targeting the cell cycle in breast cancer: towards the next phase Trisenox induces cytotoxicity through phosphorylation of mitogen-activated protein kinase molecules in acute leukemia cells Reversine inhibits Colon Carcinoma Cell Migration by Targeting JNK1

P2860

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P2860

Selective killing of p53-deficient cancer cells by SP600125.

http://www.wikidata.org/entity/Q36238666

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

@zh-hk

2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Selective killing of p53-deficient cancer cells by SP600125.

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Selective killing of p53-deficient cancer cells by SP600125.

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type

label

Selective killing of p53-deficient cancer cells by SP600125.

@ast

Selective killing of p53-deficient cancer cells by SP600125.

@en

prefLabel

Selective killing of p53-deficient cancer cells by SP600125.

@ast

Selective killing of p53-deficient cancer cells by SP600125.

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EMBO Molecular Medicine

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Selective killing of p53-deficient cancer cells by SP600125

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P2093

Antonio Antoccia

http://www.w3.org/2001/XMLSchema#string

Delphine Lissa

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Francis Harper

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Guido Kroemer

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Guillermo Mariño

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Gérard Pierron

http://www.w3.org/2001/XMLSchema#string

Lorenzo Galluzzi

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Maximilien Tailler

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Oliver Kepp

http://www.w3.org/2001/XMLSchema#string

P2860

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway

Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection

Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase

Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

P304

500-514

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scholarly article

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10.1002/EMMM.201200228

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6

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4

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Laura Senovilla

Shoaib Ahmad Malik

Francesco Berardinelli

Frédéric Schlemmer

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2012-03-21T00:00:00Z

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221967180

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22438244

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3443949

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