Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function - Test2 - elhamkhani - TriplyDB

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

http://www.wikidata.org/entity/Q27660495

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Centriole assembly and the role of Mps1: defensible or dispensable?Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor Kinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components.Polyoma small T antigen triggers cell death via mitotic catastrophe Selective Aurora Kinase Inhibitors Identified Using a Taxol-Induced Checkpoint Sensitivity Screen X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors Structure-Based Design of Orally Bioavailable 1 H -Pyrrolo[3,2- c ]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)Structural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinase High-content, high-throughput analysis of cell cycle perturbations induced by the HSP90 inhibitor XL888 Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1 Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis Characterization of a putative spindle assembly checkpoint kinase Mps1, suggests its involvement in cell division, morphogenesis and oxidative stress tolerance in Candida albicans Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure.High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons Mps1 promotes rapid centromere accumulation of Aurora B.Characterization of novel MPS1 inhibitors with preclinical anticancer activity The MPS1 family of protein kinases.Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine DNA damage to a single chromosome end delays anaphase onset How chemoproteomics can enable drug discovery and development Dynamic autophosphorylation of mps1 kinase is required for faithful mitotic progression Spindle checkpoint silencing: ensuring rapid and concerted anaphase onset Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment.Kalanchoe tubiflora extract inhibits cell proliferation by affecting the mitotic apparatus Pharmacological targeting of the pseudokinase Her3 Sensing centromere tension: Aurora B and the regulation of kinetochore function.TTK/hMPS1 is an attractive therapeutic target for triple-negative breast cancer.Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications.Bub1, Sgo1, and Mps1 mediate a distinct pathway for chromosome biorientation in budding yeast.A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers.Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.Functional viability profiles of breast cancer.

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Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

http://www.wikidata.org/entity/Q27660495

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2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

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Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

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Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

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label

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

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Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

@en

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

@nl

prefLabel

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

@ast

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

@en

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

@nl

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Nature Chemical Biology

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Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

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David Pellman

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Geert J P L Kops

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Hwan Geun Choi

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Jagesh V Shah

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Michael S Manak

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Mijung Kwon

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Nannette Jelluma

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Nathanael S Gray

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Nicholas Kwiatkowski

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Quinn L Deveraux

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P2860

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment

Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase

Mutations of mitotic checkpoint genes in human cancers

Extension of life-span by introduction of telomerase into normal human cells

Plk4-induced centriole biogenesis in human cells

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores

Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes

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359-68

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scholarly article

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3560158

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10.1038/NCHEMBIO.345

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6

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Panagis Filippakopoulos

Meera Soundararajan

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2010-05-01T00:00:00Z

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43100117

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1024590229

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20383151

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