Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.
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The amyloid hypothesis of Alzheimer's disease at 25 yearsMutations, associated with early-onset Alzheimer's disease, discovered in Asian countriesNumerical Simulations Reveal Randomness of Cu(II) Induced Aβ Peptide Dimerization under Conditions Present in Glutamatergic SynapsesBridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive PotentialFuture Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors.Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.Meta-Analysis of Serum Insulin-Like Growth Factor 1 in Alzheimer's Disease.Cutting to the chase: How pathogenic mutations cause Alzheimer's.Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production.Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.Alzheimer Disease: Scientific Breakthroughs and Translational Challenges.Protein Quality Control in Health and Disease.Evidence For and Against a Pathogenic Role of Reduced γ-Secretase Activity in Familial Alzheimer's Disease.The Emerging Roles of Early Protein Folding Events in the Secretory Pathway in the Development of Neurodegenerative Maladies.Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins.Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease.Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration.Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease.From mutated genes to familial Alzheimer's disease.CRISPR Transcriptional Activation Analysis Unmasks an Occult γ-Secretase Processivity Defect in Familial Alzheimer's Disease Skin Fibroblasts.Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis.Targeting Amyloid-β Precursor Protein, APP, Splicing with Antisense Oligonucleotides Reduces Toxic Amyloid-β Production.Reduced penetrance of the PSEN1 H163Y autosomal dominant Alzheimer mutation: a 22-year follow-up study.Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics StudyExome sequencing in an Italian family with Alzheimer's disease points to a role for seizure-related gene 6 (SEZ6) rare variant R615HDysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease
P2860
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P2860
Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.
description
2015 nî lūn-bûn
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2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
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2015年學術文章
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name
Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.
@ast
Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.
@en
type
label
Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.
@ast
Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.
@en
prefLabel
Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.
@ast
Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.
@en
P2093
P2860
P50
P356
P1476
Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.
@en
P2093
Alberto Lleo
Harrie Gijsen
Lucía Chávez-Gutiérrez
Manasi Benurwar
Maria Szaruga
Natalie S Ryan
Sam Lismont
Sarah Veugelen
Shigeo Murayama
Tammaryn Lashley
P2860
P304
P356
10.1084/JEM.20150892
P407
P577
2015-10-19T00:00:00Z