HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells.
about
Hypoxic control of metastasisSingle nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomesCD133, Selectively Targeting the Root of CancerThe Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with InflammationOverexpression of CD47 predicts poor prognosis and promotes cancer cell invasion in high-grade serous ovarian carcinoma.Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA.A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer.HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer.CD47 Promotes Tumor Invasion and Metastasis in Non-small Cell Lung Cancer.Cd47-Sirpα interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells.Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells.Evolutionary selected Tibetan variants of HIF pathway and risk of lung cancer.A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancerSelective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies.Divergent modulation of normal and neoplastic stem cells by thrombospondin-1 and CD47 signaling.The CD47-SIRPα signaling axis as an innate immune checkpoint in cancer.Maintenance of redox homeostasis by hypoxia-inducible factors.Hypoxia: Signaling the Metastatic Cascade.Leptin signaling and cancer chemoresistance: Perspectives.BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma.Hypoxic Stress-Induced Tumor and Immune Plasticity, Suppression, and Impact on Tumor Heterogeneity.Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1.Nanocarrier based approaches for targeting breast cancer stem cells.Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells.In Vitro Assays of Breast Cancer Stem Cells.CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT.CD73 Regulates Stemness and Epithelial-Mesenchymal Transition in Ovarian Cancer-Initiating Cells.The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells.Hypoxic Signalling in Tumour Stroma.BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells.Immunogenic effects of chemotherapy-induced tumor cell deathEach pregnancy linearly changes immune gene expression in the blood of healthy women compared with breast cancer patients
P2860
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P2860
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
HIF-1 regulates CD47 expressio ...... ntenance of cancer stem cells.
@ast
HIF-1 regulates CD47 expressio ...... ntenance of cancer stem cells.
@en
type
label
HIF-1 regulates CD47 expressio ...... ntenance of cancer stem cells.
@ast
HIF-1 regulates CD47 expressio ...... ntenance of cancer stem cells.
@en
prefLabel
HIF-1 regulates CD47 expressio ...... ntenance of cancer stem cells.
@ast
HIF-1 regulates CD47 expressio ...... ntenance of cancer stem cells.
@en
P2093
P2860
P356
P1476
HIF-1 regulates CD47 expressio ...... ntenance of cancer stem cells.
@en
P2093
Chuanzhao Zhang
Daniele M Gilkes
Debangshu Samanta
Haiquan Lu
Huimin Zhang
Jianjun He
John W Bullen
Lisha Xiang
P2860
P304
P356
10.1073/PNAS.1520032112
P407
P577
2015-10-28T00:00:00Z