DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa - Test2 - elhamkhani - TriplyDB

DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa

DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa

http://www.wikidata.org/entity/Q36392786

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How Is the Number of Primordial Follicles in the Ovarian Reserve Established?Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L.Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells Cell autonomous phosphoinositide 3-kinase activation in oocytes disrupts normal ovarian function through promoting survival and overgrowth of ovarian follicles.DNA damage response during mouse oocyte maturation.p63 transcriptionally regulates the expression of matrix metallopeptidase 13.Melatonin and Fertoprotective Adjuvants: Prevention against Premature Ovarian Failure during Chemotherapy.p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes.Poly (C)-binding protein 1 regulates p63 expression through mRNA stability.STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice.Tolerance to Gamma Radiation in the Tardigrade Hypsibius dujardini from Embryo to Adult Correlate Inversely with Cellular Proliferation.Effect of Previous Chemotherapy on the Quality of Cryopreserved Human Ovarian Tissue In Vitro.Folliculogenesis Is Not Fully Inhibited during GnRH Analogues Treatment in Mice Challenging Their Efficiency to Preserve the Ovarian Reserve during Chemotherapy in This Model.Different fates of oocytes with DNA double-strand breaks in vitro and in vivo A fetal whole ovarian culture model for the evaluation of CrVI-induced developmental toxicity during germ cell nest breakdown.DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age.p63 the guardian of human reproduction.Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level.The DNA damage response in mammalian oocytes.Consequences of the combined loss of BOK and BAK or BOK and BAX.Analysis of the oligomeric state and transactivation potential of TAp73α.Rescue of platinum-damaged oocytes from programmed cell death through inactivation of the p53 family signaling network Metabolic pathways regulated by TAp73 in response to oxidative stress Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis Evaluation of the BH3-only protein Puma as a direct Bak activator FANCD2 activates transcription of TAp63 and suppresses tumorigenesis LH prevents cisplatin-induced apoptosis in oocytes and preserves female fertility in mouse.Defying DNA double-strand break-induced death during prophase I meiosis by temporal TAp63α phosphorylation regulation in developing mouse oocytes.Epidermal cell junctions and their regulation by p63 in health and disease.Charged iron particles, components of space radiation, destroy ovarian follicles.Cell Death Signaling.Structural Evolution and Dynamics of the p53 Proteins.Combating radiation therapy-induced damage to the ovarian environment Tumor-Suppressor Functions of the TP53 Pathway.Chemotherapy-induced damage to ovary: mechanisms and clinical impact.A grafted ovarian fragment rescues host fertility after chemotherapy.The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-apoptotic protein BMF How to best preserve oocytes in female cancer patients exposed to DNA damage inducing therapeutics.Very low doses of heavy oxygen ion radiation induce premature ovarian failure.

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DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa

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DNA damage-induced primordial ...... ted induction of Puma and Noxa

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DNA damage-induced primordial ...... ted induction of Puma and Noxa

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P2860

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

ASPP1 and ASPP2: common activators of p53 family members

Multiple roles of ATM in monitoring and maintaining DNA integrity

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

Enhancing survival of mouse oocytes following chemotherapy or aging by targeting Bax and Rad51

Integral role of Noxa in p53-mediated apoptotic response

p63 protects the female germ line during meiotic arrest

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

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