Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels.
about
Gating mechanism of BK (Slo1) channels: so near, yet so farRegulation of bestrophin Cl channels by calcium: role of the C terminusBeta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanismsBK channels: multiple sensors, one activation gateStimulatory action of internal protons on Slo1 BK channelsGeneration of functional fluorescent BK channels by random insertion of GFP variantsZn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain.A BK (Slo1) channel journey from molecule to physiology.Cysteine residue 911 in C-terminal tail of human BK(Ca)α channel subunit is crucial for its activation by carbon monoxide.Cryo-EM structure of the open high-conductance Ca2+-activated K+ channelStepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+.Setting the stage for molecular dissection of the regulatory components of BK channels.Single-channel kinetics of BK (Slo1) channels.Tuning magnesium sensitivity of BK channels by mutations.Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.Patch clamp and perfusion techniques for studying ion channels expressed in Xenopus oocytesMg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevatedParticipation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels.The BKCa channel's Ca2+-binding sites, multiple sites, multiple ionsBarium ions selectively activate BK channels via the Ca2+-bowl siteMg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channelsNatural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channelsIntra- and intersubunit cooperativity in activation of BK channels by Ca2+Mg2+ enhances voltage sensor/gate coupling in BK channels.Cysteine modification alters voltage- and Ca(2+)-dependent gating of large conductance (BK) potassium channels.Differential effects of beta 1 and beta 2 subunits on BK channel activity.Gating and conductance properties of BK channels are modulated by the S9-S10 tail domain of the alpha subunit. A study of mSlo1 and mSlo3 wild-type and chimeric channels.Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels.Slo1 tail domains, but not the Ca2+ bowl, are required for the beta 1 subunit to increase the apparent Ca2+ sensitivity of BK channelsAllosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation siteDivalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites.Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensitivity.Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing.The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating.Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels.Heme regulates allosteric activation of the Slo1 BK channelInteraction between residues in the Mg2+-binding site regulates BK channel activationBK Channels in Cardiovascular Diseases and AgingSLO2 Channels Are Inhibited by All Divalent Cations That Activate SLO1 K+ Channels
P2860
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P2860
Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels.
@ast
Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels.
@en
type
label
Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels.
@ast
Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels.
@en
prefLabel
Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels.
@ast
Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels.
@en
P2860
P356
P1476
Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels.
@en
P2860
P304
P356
10.1085/JGP.118.5.589
P577
2001-11-01T00:00:00Z