Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464.
about
Modulating splicing with small molecular inhibitors of the spliceosomeMicrobial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer TreatmentIsolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663.Translating Nature's Library: The Bryostatins and Function-Oriented SynthesisRadiosynthesis of antitumor spliceosome modulators.An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated VirusesSF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes.Ruthenium-Catalyzed Olefin Metathesis after Tetra-n-butylammonium Fluoride-Mediated Desilylation.Chemical perturbation of Mcl-1 pre-mRNA splicing to induce apoptosis in cancer cells.Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.The psymberin story--biological properties and approaches towards total and analogue syntheses.Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy.Design and synthesis of analogues of natural products.Pre-mRNA splicing-modulatory pharmacophores: the total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives.Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1.The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1.Optimization of antitumor modulators of pre-mRNA splicing.Alternative Splicing as a Target for Cancer Treatment.
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Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
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2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
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name
Structural requirements for th ...... A splicing inhibitor FR901464.
@ast
Structural requirements for th ...... A splicing inhibitor FR901464.
@en
type
label
Structural requirements for th ...... A splicing inhibitor FR901464.
@ast
Structural requirements for th ...... A splicing inhibitor FR901464.
@en
prefLabel
Structural requirements for th ...... A splicing inhibitor FR901464.
@ast
Structural requirements for th ...... A splicing inhibitor FR901464.
@en
P2093
P2860
P356
P1476
Structural requirements for th ...... A splicing inhibitor FR901464.
@en
P2093
Brian J Albert
Kazunori Koide
Miaosheng Li
Nancy L Czaicki
Sami Osman
Yanping Wang
P2860
P304
P356
10.1002/CHEM.201002402
P407
P577
2010-11-19T00:00:00Z