High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.
about
Application of multi-target phytotherapeutic concept in malaria drug discovery: a systems biology approach in biomarker identificationNew developments in anti-malarial target candidate and product profilesA high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase-based mature gametocyte assayMutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug ResistanceNovel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screeningHundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screenLuciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes.Current therapies and future possibilities for drug development against liver-stage malaria.A broad analysis of resistance development in the malaria parasiteArtemisinin-Resistant Plasmodium falciparum Malaria.Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways.Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.The need to compare: assessing the level of agreement of three high-throughput assays against Plasmodium falciparum mature gametocytes.Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.Phenotypic Screens in Antimalarial Drug Discovery.Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic.Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity.Routine in vitro culture of P. falciparum gametocytes to evaluate novel transmission-blocking interventions.Long-term in vitro culture of Plasmodium vivax isolates from Madagascar maintained in Saimiri boliviensis blood.malERA: An updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication.malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication.Functional interrogation of Plasmodium genus metabolism identifies species- and stage-specific differences in nutrient essentiality and drug targeting.A controlled human malaria infection model enabling evaluation of transmission-blocking interventions.Recent buzz in malaria research.Hitting malaria where it hurts.Methylene blue induced morphological deformations in Plasmodium falciparum gametocytes: implications for transmission-blocking.Predicting transmission blocking potential of anti-malarial compounds in the Mosquito Feeding Assay using Plasmodium falciparum Male Gamete Inhibition Assay.Drugs in Development for Malaria.Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte StagesAntimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and aA high throughput screen for next-generation leads targeting malaria parasite transmissionA Brief Overview of Two Major Strategies in Diversity-Oriented Synthesis: Build/Couple/Pair and Ring-DistortionScreening for potential prophylactics targeting sporozoite motility through the skinChallenges and recent progress in drug discovery for tropical diseases
P2860
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P2860
High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
High-Throughput Assay and Disc ...... nterrupt Malaria Transmission.
@ast
High-Throughput Assay and Disc ...... nterrupt Malaria Transmission.
@en
type
label
High-Throughput Assay and Disc ...... nterrupt Malaria Transmission.
@ast
High-Throughput Assay and Disc ...... nterrupt Malaria Transmission.
@en
prefLabel
High-Throughput Assay and Disc ...... nterrupt Malaria Transmission.
@ast
High-Throughput Assay and Disc ...... nterrupt Malaria Transmission.
@en
P2093
P2860
P50
P1433
P1476
High-Throughput Assay and Disc ...... nterrupt Malaria Transmission.
@en
P2093
Aristea Lubar
Christina A Scherer
David M Plouffe
Didier Leroy
Eamon Comer
Erika L Flannery
Joseph Vinetz
Kailash Patra
P2860
P304
P356
10.1016/J.CHOM.2015.12.001
P577
2015-12-30T00:00:00Z