Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum - Test2 - elhamkhani - TriplyDB

Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum

Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum

http://www.wikidata.org/entity/Q24657634

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Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trial A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of Chloroquine The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso Depletion of Plasmodium berghei plasmoredoxin reveals a non-essential role for life cycle progression of the malaria parasite Neuroprotective actions of methylene blue and its derivatives Hydrogen peroxide affects contractile activity and anti-oxidant enzymes in rat uterus A high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase-based mature gametocyte assay Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau.Reactions of antimalarial peroxides with each of leucomethylene blue and dihydroflavins: flavin reductase and the cofactor model exemplified.Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito Efficacy of intravenous methylene blue, intravenous artesunate, and their combination in preclinical models of malaria.Cellular and molecular actions of Methylene Blue in the nervous system Methylene blue modulates β-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice.Simultaneous quantification of methylene blue and its major metabolite, azure B, in plasma by LC-MS/MS and its application for a pharmacokinetic study.Imaging-based high-throughput screening assay to identify new molecules with transmission-blocking potential against Plasmodium falciparum female gamete formation.Acute management of cocaine-associated methaemoglobinaemia Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action.Methylene blue inhibits function of the 5-HT transporter Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents.H2O2 dynamics in the malaria parasite Plasmodium falciparum Analyzing Thiol-Dependent Redox Networks in the Presence of Methylene Blue and Other Antimalarial Agents with RT-PCR-Supported in silico Modeling.High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain.Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots.1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agents Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs.Co-ordinated stage-dependent enhancement of Plasmodium falciparum antioxidant enzymes and heat shock protein expression in parasites growing in oxidatively stressed or G6PD-deficient red blood cells.Structure-activity relationship of cyanine tau aggregation inhibitors.Cytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis.Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue.Immunotherapy for Alzheimer's disease: from anti-β-amyloid to tau-based immunization strategies.Plasmodium cell biology should inform strategies used in the development of antimalarial transmission-blocking drugs.Toxicity of imine-iminium dyes and pigments: electron transfer, radicals, oxidative stress and other physiological effects.P2X7 receptor as a novel drug delivery system to increase the entrance of hydrophilic drugs into cells during photodynamic therapy.Mitochondrial optic neuropathy: In vivo model of neurodegeneration and neuroprotective strategies.Synthesis of a photostable near-infrared-absorbing photosensitizer for selective photodamage to cancer cells.Synthesis and antimalarial properties of streptocyanine dyes.Antiplasmodial activities of dyes against Plasmodium falciparum asexual and sexual stages: Contrasted uptakes of triarylmethanes Brilliant green, Green S (E142), and Patent Blue V (E131) by erythrocytes.

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P2860

Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum

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Interactions of methylene blue ...... ues from Plasmodium falciparum

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Antimicrobial Agents and Chemotherapy

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Interactions of methylene blue ...... ues from Plasmodium falciparum

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Jana K Eubel

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Kathrin Buchholz

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Monique B Akoachere

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R Heiner Schirmer

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Stephan Gromer

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P2860

Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine

Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841]

Tissue sulfhydryl groups

Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development

The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases

HEREDITARY DIAPHORASE DEFICIENCY AND METHEMOGLOBINEMIA

Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

Glutathione--functions and metabolism in the malarial parasite Plasmodium falciparum.

The thioredoxin system--from science to clinic.

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183-91

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10.1128/AAC.00773-07

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1

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52

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Thomas Dandekar

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5878186

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infectious disease

Plasmodium falciparum

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2223905

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