about
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stressForever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegenerationInterplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogrammingLimited clinical relevance of mitochondrial DNA mutation and gene expression analyses in ovarian cancer.mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft.Hypothesis: Bifunctional mitochondrial proteins have centrosomal functionsNKX6.3 Regulates Reactive Oxygen Species Production by Suppressing NF-kB and DNMT1 Activities in Gastric Epithelial Cells.SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress.MnSOD activity protects mitochondrial morphology of quiescent fibroblasts from age associated abnormalitiesMitochondrial genome regulates mitotic fidelity by maintaining centrosomal homeostasis.The mitochondrial genome is a "genetic sanctuary" during the oncogenic process.Sirt3, mitochondrial ROS, ageing, and carcinogenesis.Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ.SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria.Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stagesMitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: a biomarker for the early detection of cancer.The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer CellsSirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status.Protective effects of selenium against DNA adduct formation in Inuit environmentally exposed to PCBsMitochondrial regulation of epigenetics and its role in human diseases.Radon-induced reduced apoptosis in human bronchial epithelial cells with knockdown of mitochondria DNAClinical oxidation parameters of aging.Microarray analysis of ageing-related signatures and their expression in tumors based on a computational biology approachSIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression.Mitochondria and familial predisposition to breast cancer.Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction.Mitochondria as a target of environmental toxicants.Gamma rays induce a p53-independent mitochondrial biogenesis that is counter-regulated by HIF1α.Lifestyle and nutrition, caloric restriction, mitochondrial health and hormones: scientific interventions for anti-aging.Mitochondrial DNA repair in aging and diseaseISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiaep53 regulates mtDNA copy number and mitocheckpoint pathway.Naive CD4 T cells from aged mice show enhanced death upon primary activationMitochondrial DNA mutations and breast tumorigenesis.Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis.SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis.Oxidative stress and therapeutic opportunities: focus on the Ewing's sarcoma family of tumors.The dual role of sirtuins in cancer.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Mitochondria damage checkpoint, aging, and cancer.
@ast
Mitochondria damage checkpoint, aging, and cancer.
@en
type
label
Mitochondria damage checkpoint, aging, and cancer.
@ast
Mitochondria damage checkpoint, aging, and cancer.
@en
prefLabel
Mitochondria damage checkpoint, aging, and cancer.
@ast
Mitochondria damage checkpoint, aging, and cancer.
@en
P2860
P356
P1476
Mitochondria damage checkpoint, aging, and cancer.
@en
P2093
Keshav K Singh
P2860
P304
P356
10.1196/ANNALS.1354.022
P407
P577
2006-05-01T00:00:00Z