Insights into the role of heme in the mechanism of action of antimalarials. - Test2 - elhamkhani - TriplyDB

Insights into the role of heme in the mechanism of action of antimalarials.

Insights into the role of heme in the mechanism of action of antimalarials.

http://www.wikidata.org/entity/Q36544899

about

Phospholipid membrane-mediated hemozoin formation: the effects of physical properties and evidence of membrane surrounding hemozoin A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya Artemisinin Action and Resistance in Plasmodium falciparum Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter Inhibition of an Erythrocyte Tyrosine Kinase with Imatinib Prevents Plasmodium falciparum Egress and Terminates Parasitemia Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology Hemozoin and antimalarial drug discovery Malarial hemozoin: from target to tool Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity.Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity.Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery.Identification of β-hematin inhibitors in the MMV Malaria Box Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials.Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model.Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum.Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum.Breakdown of phosphatidylserine asymmetry following treatment of erythrocytes with lumefantrine.Quantification of labile heme in live malaria parasites using a genetically encoded biosensor Dual-functioning antimalarials that inhibit the chloroquine-resistance transporter.Adverse neuropsychiatric effects of antimalarial drugs.Using a genome-scale metabolic network model to elucidate the mechanism of chloroquine action in Plasmodium falciparum Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.Detergent-Mediated Formation of β-Hematin: Heme Crystallization Promoted by Detergents Implicates Nanostructure Formation for Use as a Biological Mimic.Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic.Metabolic Dysregulation Induced in Plasmodium falciparum by Dihydroartemisinin and Other Front-Line Antimalarial Drugs.ATP and luciferase assays to determine the rate of drug action in in vitro cultures of Plasmodium falciparum.The ferroquine antimalarial conundrum: redox activation and reinvasion inhibition.Plasmodium heme biosynthesis: To be or not to be essential?Synthetic Hemozoin (β-Hematin) Crystals Nucleate at the Surface of Neutral Lipid Droplets that Control Their Sizes.A computational study of ligand binding affinities in iron(III) porphine and protoporphyrin IX complexes.Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum.Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum.High-Content Screening of MMV Pathogen Box for Plasmodium falciparum Digestive Vacuole Disrupting Molecules Reveals Valuable Starting Points for Drug Discovery.Genotoxic effects of the antimalarial drug lumefantrine in human lymphocytes in vitro and computational prediction of the mechanism associated with its interaction with DNA.Palladium-catalyzed intermolecular oxidative cyclization of N-aryl enamines with isocyanides through double sp(2) C-H bonds cleavage: facile synthesis of 4-aminoquinoline derivatives.Study of the antimalarial activity of 4-aminoquinoline compounds against chloroquine-sensitive and chloroquine-resistant parasite strains

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P2860

Insights into the role of heme in the mechanism of action of antimalarials.

http://www.wikidata.org/entity/Q36544899

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Insights into the role of heme in the mechanism of action of antimalarials.

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Insights into the role of heme in the mechanism of action of antimalarials.

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type

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Insights into the role of heme in the mechanism of action of antimalarials.

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Insights into the role of heme in the mechanism of action of antimalarials.

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Insights into the role of heme in the mechanism of action of antimalarials.

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Insights into the role of heme in the mechanism of action of antimalarials.

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ACS Chemical Biology

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Insights into the role of heme in the mechanism of action of antimalarials.

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Dale Taylor

http://www.w3.org/2001/XMLSchema#string

Jill M Combrinck

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Kanyile K Ncokazi

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Melvin A Ambele

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Peter J Smith

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Tebogo E Mabotha

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Timothy J Egan

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P2860

The Plasmodium falciparum-infected red blood cell

Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation

Artemisinins target the SERCA of Plasmodium falciparum

Thousands of chemical starting points for antimalarial lead identification

On the molecular mechanism of chloroquine's antimalarial action

Human malaria parasites in continuous culture

Chemical genetics of Plasmodium falciparum

The neutral lipid composition present in the digestive vacuole of Plasmodium falciparum concentrates heme and mediates β-hematin formation with an unusually low activation energy.

The structure of malaria pigment beta-haematin.

Colorimetric high-throughput screen for detection of heme crystallization inhibitors.

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133-137

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10.1021/CB300454T

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1

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Heinrich C. Hoppe

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2012-10-11T00:00:00Z

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232221895

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