Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
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Artemisinins: their growing importance in medicineEvidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugsAnti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract--possible synergistic and resistance mechanismsA novel way to grow hemozoin-like crystals in vitro and its use to screen for hemozoin inhibiting antimalarial compoundsHemozoin and antimalarial drug discoveryThe binding modes and binding affinities of artemisinin derivatives with Plasmodium falciparum Ca2+-ATPase (PfATP6).Plasmodium drug targets outside the genetic control of the parasite.Discovery, mechanisms of action and combination therapy of artemisininInsights into the role of heme in the mechanism of action of antimalarials.Malaria and iron: history and review.Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potentialCharacterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds.Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin.Trioxaquines and heme-artemisinin adducts inhibit the in vitro formation of hemozoin better than chloroquine.Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance.Interaction of artemisinins with oxyhemoglobin Hb-FeII, Hb-FeII, carboxyHb-FeII, heme-FeII, and carboxyheme FeII: significance for mode of action and implications for therapy of cerebral malaria.Convenient access both to highly antimalaria-active 10-arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate.Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins.
P2860
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P2860
Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
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Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
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Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
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Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
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type
label
Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
@ast
Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
@en
Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
@en-gb
Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
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Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
@ast
Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
@en
Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
@en-gb
Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
@nl
P2093
P2860
P50
P921
P1476
Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation
@en
P2093
Diego Monti
Nicoletta Basilico
Silvia Parapini
P2860
P356
10.1128/AAC.47.3.1175.2003
P407
P577
2003-03-01T00:00:00Z