Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome.
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Spatial Genome Organization and Its Emerging Role as a Potential Diagnosis ToolThe second decade of 3C technologies: detailed insights into nuclear organizationOld cells, new tricks: chromatin structure in senescenceEpigenetic modulators, modifiers and mediators in cancer aetiology and progressionMolecular insights into the premature aging disease progeriaHistones and histone modifications in perinuclear chromatin anchoring: from yeast to manMolecular turnover, the H3.3 dilemma and organismal aging (hypothesis)Reorganization of chromosome architecture in replicative cellular senescenceSpinning the web of cell fate.Recent advances in understanding the role of lamins in health and diseasePhysiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear EdgeC-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin OrganizationTRF2 and lamin A/C interact to facilitate the functional organization of chromosome endsExpression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior.The sequencing bias relaxed characteristics of Hi-C derived data and implications for chromatin 3D modelingReconstructing A/B compartments as revealed by Hi-C using long-range correlations in epigenetic data.Specifying peripheral heterochromatin during nuclear lamina reassembly.Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targetingMechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territoriesTransformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4.DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome.Histone methylation and aging: lessons learned from model systems.Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins.Long-Range Chromatin InteractionsIdentification of lamin B-regulated chromatin regions based on chromatin landscapes.Characterization of DNA methylation as a function of biological complexity via dinucleotide inter-distances.Structural heterogeneity and functional diversity of topologically associating domains in mammalian genomes.Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria.Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cellsNuclear mechanics in cancerProliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteinsGene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells.Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria SyndromeGlobal genome splicing analysis reveals an increased number of alternatively spliced genes with aging.Resolving spatial inconsistencies in chromosome conformation measurementsBarrier-to-autointegration factor (BAF) involvement in prelamin A-related chromatin organization changes.Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape.Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes.The spindle assembly checkpoint: More than just keeping track of the spindle.
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P2860
Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Correlated alterations in geno ...... son-Gilford progeria syndrome.
@ast
Correlated alterations in geno ...... son-Gilford progeria syndrome.
@en
type
label
Correlated alterations in geno ...... son-Gilford progeria syndrome.
@ast
Correlated alterations in geno ...... son-Gilford progeria syndrome.
@en
prefLabel
Correlated alterations in geno ...... son-Gilford progeria syndrome.
@ast
Correlated alterations in geno ...... son-Gilford progeria syndrome.
@en
P2093
P2860
P356
P1433
P1476
Correlated alterations in geno ...... son-Gilford progeria syndrome.
@en
P2093
Ashley Nazario-Toole
Haoyue Zhang
Job Dekker
Michael R Erdos
Peter S Chines
P2860
P304
P356
10.1101/GR.138032.112
P577
2012-11-14T00:00:00Z