Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
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Mitochondrial metabolic remodeling in response to genetic and environmental perturbationsDefects in mitochondrial metabolism and cancerOncometabolites: Unconventional triggers of oncogenic signalling cascadesChanging perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agentsMild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's diseaseThe succinated proteome.Uterine smooth muscle tumors with features suggesting fumarate hydratase aberration: detailed morphologic analysis and correlation with S-(2-succino)-cysteine immunohistochemistry.Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.Mitochondrial Deficiencies in the Predisposition to ParagangliomaThe Succinated Proteome of FH-Mutant TumoursOncometabolites: linking altered metabolism with cancer.Identification of protein succination as a novel modification of tubulinSuccination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome.Complex role of HIF in cancer: the known, the unknown, and the unexpected.Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions.Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry.Rare insights into cancer biology.Metabolic control of signalling pathways and metabolic auto-regulation.Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors.Leiomyoma with bizarre nuclei: a morphological, immunohistochemical and molecular analysis of 31 cases.SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.Molecular Pathogenesis and Diagnostic, Prognostic and Predictive Molecular Markers in Sarcoma.Altered metabolite levels in cancer: implications for tumour biology and cancer therapy.A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors.Succination of Protein Disulfide Isomerase Links Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes.IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas.Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive DiabetesExploiting tumor metabolism: challenges for clinical translation.Adipocyte protein modification by Krebs cycle intermediates and fumarate ester-derived succination.Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes.Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects.The role of metabolic enzymes in mesenchymal tumors and tumor syndromes: genetics, pathology, and molecular mechanisms.Metabolic Alterations in Cancer Cells and the Emerging Role of Oncometabolites as Drivers of Neoplastic Change.Metabolic implications of hypoxia and pseudohypoxia in pheochromocytoma and paraganglioma.Identification of a metabolic disposal route for the oncometabolite S-(2-succino)cysteine in Bacillus subtilis.Mitochondrial Complex I activity signals antioxidant response through ERK5.Human Fumarate Hydratase Is Dual Localized by an Alternative Transcription Initiation MechanismTetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation
P2860
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P2860
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
@ast
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
@en
type
label
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
@ast
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
@en
prefLabel
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
@ast
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
@en
P2093
P2860
P50
P1433
P1476
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
@en
P2093
Alexandre Berquand
Kaori Igarashi
Kaori Saito
Kathryn Wolhulter
Keiko Kato
Linda O'Flaherty
Mahima Laroyia
Mitsuhiro Kitagawa
Norma Frizzell
P2860
P304
P356
10.1016/J.CELREP.2013.02.013
P577
2013-03-14T00:00:00Z