The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture.
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Papillomavirus genome structure, expression, and post-transcriptional regulationInhibition of p53 DNA binding by human papillomavirus E6 proteinsThe E7 oncoprotein is translated from spliced E6*I transcripts in high-risk human papillomavirus type 16- or type 18-positive cervical cancer cell lines via translation reinitiationHuman papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activityHuman papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcriptionA Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma VirusesPapillomavirus E6 oncoproteins.Genomic diversity and interspecies host infection of alpha12 Macaca fascicularis papillomaviruses (MfPVs).Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytesHuman papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligaseHPV-16 E2 gene disruption and sequence variation in CIN 3 lesions and invasive squamous cell carcinomas of the cervix: relation to numerical chromosome abnormalities.Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins.The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.Human papillomavirus type 16 E1circumflexE4 contributes to multiple facets of the papillomavirus life cycle.Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells.Signals that dictate nuclear localization of human papillomavirus type 16 oncoprotein E6 in living cellsViral oncogenes, noncoding RNAs, and RNA splicing in human tumor virusesE6-associated transcription patterns in human papilloma virus 16-positive cervical tissuesThe HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor speciesWarts, cancer and ubiquitylation: lessons from the papillomaviruses.A prime/boost strategy using DNA/fowlpox recombinants expressing the genetically attenuated E6 protein as a putative vaccine against HPV-16-associated cancers.Cervical cancer: is herpes simplex virus type II a cofactor?Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor genePATJ, a tight junction-associated PDZ protein, is a novel degradation target of high-risk human papillomavirus E6 and the alternatively spliced isoform 18 E6The large and small isoforms of human papillomavirus type 16 E6 bind to and differentially affect procaspase 8 stability and activityTranslation of the human papillomavirus type 16 E7 oncoprotein from bicistronic mRNA is independent of splicing events within the E6 open reading frame.Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells.Serum- and calcium-induced differentiation of human keratinocytes is inhibited by the E6 oncoprotein of human papillomavirus type 16.Natural variants of the human papillomavirus type 16 E6 protein differ in their abilities to alter keratinocyte differentiation and to induce p53 degradation.Enhanced transcriptional activation by E2 proteins from the oncogenic human papillomavirusesCervical keratinocytes containing stably replicating extrachromosomal HPV-16 are refractory to transformation by oncogenic H-Ras.The Asian-American E6 variant protein of human papillomavirus 16 alone is sufficient to promote immortalization, transformation, and migration of primary human foreskin keratinocytes.Comprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversityProteomic approaches to the study of papillomavirus-host interactions.Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1.Papillomavirus E7 protein binding to the retinoblastoma protein is not required for viral induction of warts.Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein.Transcriptional activation of several heterologous promoters by the E6 protein of human papillomavirus type 16.Identification of three transforming proteins encoded by cottontail rabbit papillomavirus.
P2860
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P2860
The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
The full-length E6 protein of ...... lize keratinocytes in culture.
@en
type
label
The full-length E6 protein of ...... lize keratinocytes in culture.
@en
prefLabel
The full-length E6 protein of ...... lize keratinocytes in culture.
@en
P2093
P2860
P1433
P1476
The full-length E6 protein of ...... lize keratinocytes in culture.
@en
P2093
J T Schiller
M S Barbosa
N L Hubbert
S A Sedman
P2860
P304
P407
P577
1991-09-01T00:00:00Z