Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion - Test2 - elhamkhani - TriplyDB

Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion

Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion

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Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer Aurora kinase A in gastrointestinal cancers: time to target Asymmetric cell division of stem and progenitor cells during homeostasis and cancer NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner.Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer Aurora kinases: novel therapy targets in cancers Aurora kinase A is not involved in CPEB1 phosphorylation and cyclin B1 mRNA polyadenylation during meiotic maturation of porcine oocytes AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers.Issues in interpreting the in vivo activity of Aurora-A Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells A non-mitotic role for Aurora kinase A as a direct activator of cell migration upon interaction with PLD, FAK and Src.Aurora-A promotes chemoresistance in hepatocelluar carcinoma by targeting NF-kappaB/microRNA-21/PTEN signaling pathway.Aurora kinase A has a significant role as a therapeutic target and clinical biomarker in endometrial cancer.Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth.Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis Mutant p53 expression in fallopian tube epithelium drives cell migration Danusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells.AurkA controls self-renewal of breast cancer-initiating cells promoting wnt3a stabilization through suppression of miR-128 Network analysis identifies an HSP90-central hub susceptible in ovarian cancer AURKA induces EMT by regulating histone modification through Wnt/β-catenin and PI3K/Akt signaling pathway in gastric cancer.UBE2C induces EMT through Wnt/β‑catenin and PI3K/Akt signaling pathways by regulating phosphorylation levels of Aurora-A.Alisertib induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt/mTOR- and p38 MAPK-mediated pathways in human glioblastoma cells An update on the pharmacokinetics and pharmacodynamics of alisertib, a selective Aurora kinase A inhibitor.Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy.Association between the functional polymorphism Ile31Phe in the AURKA gene and susceptibility of hepatocellular carcinoma in chronic hepatitis B virus carriers.A SILAC-based proteomics elicits the molecular interactome of alisertib (MLN8237) in human erythroleukemia K562 cells.Time-lapse lens-free imaging of cell migration in diverse physical microenvironments.ARD1-mediated aurora kinase A acetylation promotes cell proliferation and migration.Aurora A kinase regulates non-homologous end-joining and poly(ADP-ribose) polymerase function in ovarian carcinoma cells AURKA inhibition mimics BRCAness Loss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancer Aurora A kinase activates YAP signaling in triple-negative breast cancer.Silencing Aurora A leads to re-sensitization of breast cancer cells to Taxol through downregulation of SRC-mediated ERK and mTOR pathways.Alisertib promotes apoptosis and autophagy in melanoma through p38 MAPK-mediated aurora a signaling.Network analysis revealed aurora kinase dysregulation in five gynecological types of cancer.Target Identification of Kinase Inhibitor Alisertib (MLN8237) by Using DNA-Programmed Affinity Labeling.The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC.Effect of AURKA Gene Expression Knockdown on Angiogenesis and Tumorigenesis of Human Ovarian Cancer Cell Lines.Increased AURKA Gene Copy Number Correlates with Poor Prognosis and Predicts the Efficacy of High-dose Interferon Therapy in Acral Melanoma.

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Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion

http://www.wikidata.org/entity/Q36807632

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2013 nî lūn-bûn

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2013年论文

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name

Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion

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Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion

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Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion

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Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion

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Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion

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Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion

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Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion

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A J Klein-Szanto

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A K Godwin

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C Howe

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D C Connolly

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E A Golemis

http://www.w3.org/2001/XMLSchema#string

F Xiao

http://www.w3.org/2001/XMLSchema#string

H B Pathak

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J A Ecsedy

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L E Bickel

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M Maglaty

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P2860

CAS proteins in normal and pathological cell growth control

A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9

Inhibitors targeting mitosis: tales of how great drugs against a promising target were brought down by a flawed rationale

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.

Cancer statistics, 2008

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome

HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

A renaissance for SRC

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539-549

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10.1038/ONC.2012.632

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