PINK1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced AKT and increased p38 MAPK activation, and downregulation of EGFR.
about
LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.FTSJ2, a heat shock-inducible mitochondrial protein, suppresses cell invasion and migration.Loss of PINK1 impairs stress-induced autophagy and cell survivalPINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes.PINK1 Deficiency Enhances Inflammatory Cytokine Release from Acutely Prepared Brain Slices.Compromised MAPK signaling in human diseases: an update.PINK1 Deficiency Decreases Expression Levels of mir-326, mir-330, and mir-3099 during Brain Development and Neural Stem Cell Differentiation.PINK1 phosphorylates transglutaminase 2 and blocks its proteasomal degradation.Silencing of PINK1 inhibits insulin-like growth factor-1-mediated receptor activation and neuronal survival.Metabolic Dysfunction in Parkinson's Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism.The Role of Astrocyte Dysfunction in Parkinson's Disease Pathogenesis.Suppression of miR-155 Expression in IFN-γ-Treated Astrocytes and Microglia by DJ-1: A Possible Mechanism for Maintaining SOCS1 Expression.Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo.PDGF-BB Preserves Mitochondrial Morphology, Attenuates ROS Production, and Upregulates Neuroglobin in an Astrocytic Model Under Rotenone Insult.A Parkinson's disease gene, DJ-1, repairs brain injury through Sox9 stabilization and astrogliosis.Astrocyte-Specific Deletion of Sox2 Promotes Functional Recovery After Traumatic Brain Injury.Regulation of mitochondrial dynamics in astrocytes: Mechanisms, consequences, and unknowns.Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death.Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease.Astrocytes as targets for drug discovery.Astrocytes in a dish: Using pluripotent stem cells to model neurodegenerative and neurodevelopmental disorders.Astrocytes, Microglia, and Parkinson's Disease.
P2860
Q27322966-FAB6C660-0288-4182-BEA4-90ECFA70B31DQ35111112-631A703A-60AC-4830-BCA0-05CD630B4D69Q35153949-22DE08F0-FC14-4906-A1BF-029E950CD250Q36446405-2F54213F-1A89-4160-8FBB-B4B1A3434151Q36750245-EA3317BE-F63B-437B-9700-AF1EE689CA39Q38359194-7151045A-1EC4-4302-8260-3001B319ED43Q38619356-3A78AC8E-DEF4-4E50-ABD6-D29E56BD6D95Q38923448-5FE30F5B-0C24-453F-B21D-9F0D701F2F55Q38926013-C81B21BE-4895-41F9-B324-B0758636EC42Q39199926-F62EE932-84DB-4EA0-A480-BA06CF939125Q39319763-A467F157-83E0-45A3-A8D1-E01DB1480264Q40965307-66030885-4A69-4F0B-81AE-4A1D61A6C1BFQ41228349-593A27E6-489A-4A4D-8C78-0891E48797BAQ45305356-4E24F02A-664A-4C3E-9AB4-E0DF1B283473Q46372774-0003312E-A0D1-4140-BFA3-6202C7190AEDQ47438534-F7D5968A-C15A-4321-A16C-5626AE63ADFFQ47958146-F079BF49-82FF-4F85-A3CC-B2078F456575Q47988844-4D4DDA6C-4768-4E26-B158-B907E910CE0AQ48267087-06ACA2BB-A1E9-43BE-9E7D-1B4327BEC6D9Q48357636-5CA8126C-C776-4F73-8044-D53C3608D249Q50113762-62D1D908-0AE3-4E66-B346-D21658B12573Q52092430-9BAA8BC5-7E9A-4F6A-9212-663CACBACB36Q55000928-BBDC4FEA-938B-4C87-9573-350F812A84AB
P2860
PINK1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced AKT and increased p38 MAPK activation, and downregulation of EGFR.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
PINK1 deficiency attenuates as ...... n, and downregulation of EGFR.
@en
type
label
PINK1 deficiency attenuates as ...... n, and downregulation of EGFR.
@en
prefLabel
PINK1 deficiency attenuates as ...... n, and downregulation of EGFR.
@en
P2093
P2860
P356
P1433
P1476
PINK1 deficiency attenuates as ...... on, and downregulation of EGFR
@en
P2093
Beomsue Kim
Eun-Hye Joe
Hey-Kyeong Jeong
Insup Choi
Linan Chen
Sang Myun Park
Xiaoxi Zhuang
P2860
P304
P356
10.1002/GLIA.22475
P50
P577
2013-02-26T00:00:00Z