Hereditary early-onset Parkinson's disease caused by mutations in PINK1
about
The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old ageA two-stage meta-analysis identifies several new loci for Parkinson's diseaseWeb-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's diseaseBrain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's diseaseThe phosphorylation-dependent regulation of mitochondrial proteins in stress responsesParkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondriaGenetic perspective on the role of the autophagy-lysosome pathway in Parkinson diseaseGenetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation updateParkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activityThe genetic epidemiology of neurodegenerative disease.Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65Ubiquitin is phosphorylated by PINK1 to activate parkinParkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicityPINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motilityPARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neuronsThe mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 traffickingParkin ubiquitinates and promotes the degradation of RanBP2The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagyMUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkinPINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagyMutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stabilityMitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cellsIdentification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screenMitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagyPhosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neuronsInteraction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell deathAutoregulation of Parkin activity through its ubiquitin-like domainThe Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formationBiochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)The role of oxidative stress in Parkinson's diseaseHigh-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagyPINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradationPhosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signalingPINK1 cleavage at position A103 by the mitochondrial protease PARL.Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthoodLoss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fissionThe kinase domain of mitochondrial PINK1 faces the cytoplasm
P2860
Q21090191-A6907529-E49D-4019-95E4-1BC3AC793E4FQ21144948-3E7C771A-EE21-4E4A-A25D-696DC044D799Q21144949-1A9BB903-72B6-4910-AFF3-68B1BF36D8D5Q21245635-122989FA-7DEA-4E86-B18C-5756FB029E8DQ21285141-E8F5A57B-1364-4984-B2BC-1CB6E2588865Q21563375-E1025C2E-D25D-4BD1-B945-7893346ABB20Q22242985-D9F84FEC-CBC9-46BC-9533-0DEFF877C6CCQ22252904-1AD586D7-7BC1-4E74-A42F-056940FC50AEQ22254785-5ED23B0C-A79E-4374-B32F-4AC1EEE16E25Q22306301-0C3633EF-3D79-4BFF-BAB6-2A0F7A383B95Q24292901-DAD00626-3707-4EE8-B3DA-52EFC94AC309Q24296532-A2CE2E37-980A-4406-92A9-C3B084888ED1Q24296667-DB285D90-CCA8-4302-A5A5-367C8D5ADD87Q24296955-00611C07-E369-4498-8B4E-7DC7A60A0178Q24297072-E69B8C9F-ACC2-42A5-99F7-81F6167FF06BQ24297960-F112AC25-0001-4E9F-BA9F-1C3552A9C203Q24298223-64AB4BA2-8A32-475E-8274-6BEE388E2911Q24298748-90D7F4FD-E6FD-48A5-B73F-0265DC9E0BFFQ24298771-69BE779F-73A1-40AF-ABD6-67D3B2F8135DQ24299149-8B68E922-F108-4E07-A26A-507C9E6C3D95Q24299939-6E67FBCA-CE95-49B4-80E3-BA222B776D90Q24300095-E8072619-095E-4AD4-A460-01734B6416E5Q24300657-58A13924-812B-4CA6-98DB-30677338183FQ24300975-706B7028-5966-443A-A944-08C3807FEAD3Q24305292-E5DBAC52-D903-406A-BC86-57130441AD2EQ24306270-EF180CE6-2C80-408A-983E-1B2F369F1D45Q24307382-85A1E657-D10E-4D31-AFEA-10BDB166C0E8Q24307589-996D7AB6-11D1-477C-99E0-E15A9AD654DEQ24307730-E4F1AE34-AD64-430D-8AF8-DA6887442C98Q24307946-DCC26EC5-9707-45AA-964A-6575206AEAD3Q24309613-8236D79D-2D2C-458E-928D-B9E21EAEB4E6Q24310717-08D45DCF-6049-4EA9-B621-3E54945CAC76Q24312106-4200E955-5DF9-40D2-B6AC-F69864A8EE84Q24312713-756F4C32-7943-4F3B-B638-556C856183F1Q24313304-D45E239F-1D98-45FA-AFD8-8BEFE245BF4CQ24313472-5D15593B-62E8-4949-8DF7-40098B9FDF7CQ24315046-96FF9FCE-E861-41D2-BDA7-BF0DA6C83AADQ24320029-1A1A4D66-90E2-48B0-ABD3-A95488EE86F0Q24320327-8172F204-401B-4D7D-B37A-A6AA8A6E8625Q24321709-476A752A-B28C-454B-A113-174383064D0E
P2860
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
description
2004 nî lūn-bûn
@nan
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
@ast
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
@en
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
@en-gb
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
@nl
type
label
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
@ast
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
@en
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
@en-gb
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
@nl
prefLabel
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
@ast
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
@en
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
@en-gb
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
@nl
P2093
P50
P921
P3181
P356
P1433
P1476
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
@en
P2093
Daniel G Healy
David S Latchman
Domenico Del Turco
Georg Auburger
Kirsten Harvey
Miratul M K Muqit
Patrick M Abou-Sleiman
Rafael González-Maldonado
Robert Nussbaum
Sergio Salvi
P304
P356
10.1126/SCIENCE.1096284
P407
P50
P577
2004-05-21T00:00:00Z