Abi1 gene silencing by short hairpin RNA impairs Bcr-Abl-induced cell adhesion and migration in vitro and leukemogenesis in vivo.
about
Identification and functional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1The proximal signaling network of the BCR-ABL1 oncogene shows a modular organizationInteractome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactorInhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cellsFunctional mechanisms and roles of adaptor proteins in abl-regulated cytoskeletal actin dynamics.Expression of Abelson interactor 1 (Abi1) correlates with inflammation, KRAS mutation and adenomatous change during colonic carcinogenesis.Phosphatidylinositol 3-kinase CB association with preoperative radiotherapy response in rectal adenocarcinomaCDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis.Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice.Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton.Transducer of Cdc42-dependent actin assembly promotes epidermal growth factor-induced cell motility and invasivenessBcr-Abl activates AURKA and AURKB in chronic myeloid leukemia cells via AKT signaling.Abl-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukaemic cell adhesion.The anti-invasive activity of synthetic alkaloid ethoxyfagaronine on L1210 leukemia cells is mediated by down-regulation of plasminogen activators and MT1-MMP expression and activity.G-protein coupled receptor 34 activates Erk and phosphatidylinositol 3-kinase/Akt pathways and functions as alternative pathway to mediate p185Bcr-Abl-induced transformation and leukemogenesis.
P2860
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P2860
Abi1 gene silencing by short hairpin RNA impairs Bcr-Abl-induced cell adhesion and migration in vitro and leukemogenesis in vivo.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Abi1 gene silencing by short h ...... ro and leukemogenesis in vivo.
@en
type
label
Abi1 gene silencing by short h ...... ro and leukemogenesis in vivo.
@en
prefLabel
Abi1 gene silencing by short h ...... ro and leukemogenesis in vivo.
@en
P2093
P2860
P356
P1433
P1476
Abi1 gene silencing by short h ...... ro and leukemogenesis in vivo.
@en
P2093
Everardo Cobos
Nancy Clough
Weidong Yu
Xiaolin Sun
Yunxia Tao
Zonghan Dai
P2860
P304
P356
10.1093/CARCIN/BGN098
P407
P577
2008-05-02T00:00:00Z